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The transcription factor Snail, an extremely unstable protein whose subcellular levels are regulated by many E3 ubiquitin ligases, promotes EMT as well as associated pathological characteristics including migration, invasion, and metastasis. Through yeast two\u2010hybrid screening, we identified the carboxyl terminus of Hsc70\u2010interacting protein (CHIP) as a novel Snail ubiquitin ligase that interacts with Snail to induce ubiquitin\u2010mediated proteasomal degradation. Inhibition of CHIP expression increases Snail protein levels, induces EMT, and enhances <jats:italic>in\u00a0vitro<\/jats:italic> migration and invasion as well as <jats:italic>in\u00a0vivo<\/jats:italic> metastasis of ovarian cancer cells. In turn, Snail depletion abrogates all phenomena induced by CHIP depletion. Finally, Snail and CHIP expression is inversely correlated in ovarian tumor tissues. These findings establish the CHIP\u2013Snail axis as a post\u2010translational mechanism of EMT and cancer metastasis regulation.<\/jats:p>","DOI":"10.1002\/1878-0261.12485","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T16:59:51Z","timestamp":1553965191000},"page":"1280-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Downregulation of CHIP promotes ovarian cancer metastasis by inducing Snail\u2010mediated epithelial\u2013mesenchymal transition"],"prefix":"10.1002","volume":"13","author":[{"given":"Sun\u2010Mi","family":"Park","sequence":"first","affiliation":[{"name":"Division of Applied Life Science (BK21 Plus) Research Institute of Life Sciences Gyeongsang National University Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Environmental Disease Research Center 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