{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:10Z","timestamp":1790035210817,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671611"],"award-info":[{"award-number":["81671611"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172783"],"award-info":[{"award-number":["81172783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) is a malignancy with one of the worst prognoses. Long noncoding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) are emerging as an important regulator of gene expression and function, leading to the development of cancer. The aim of this study was to determine the relationship between lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> and to further guide clinical therapy. lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> and adjacent tissues were screened, and the correlation between lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDPK<\/jats:styled-content>2P expression in liver tissues and the pathological characteristics and severity of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> was assessed. The effects of <jats:styled-content style=\"fixed-case\">PDPK<\/jats:styled-content>2P on <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> proliferation, apoptosis, metastasis, and invasion were also systematically investigated <jats:italic>via <\/jats:italic><jats:styled-content style=\"fixed-case\">CCK<\/jats:styled-content>\u20108 assay, flow cytometry, scratch wound healing, and transwell assay, respectively. The relationship between <jats:styled-content style=\"fixed-case\">PDPK<\/jats:styled-content>2P and <jats:styled-content style=\"fixed-case\">PDK<\/jats:styled-content>1 was verified by <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> pull\u2010down, rescue experiments and western blot. lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDPK<\/jats:styled-content>2P was highly expressed in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> tissues with a distinct positive correlation between <jats:styled-content style=\"fixed-case\">PDPK<\/jats:styled-content>2P and <jats:styled-content style=\"fixed-case\">PDK<\/jats:styled-content>1, and the upregulation was clinically associated with a larger tumor embolus, low differentiation, and poor survival. Mechanistically, lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDPK<\/jats:styled-content>2P interacted with <jats:styled-content style=\"fixed-case\">PDK<\/jats:styled-content>1 and promoted <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> progression through the <jats:styled-content style=\"fixed-case\">PDK<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>\/caspase 3 signaling pathway. lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDPK<\/jats:styled-content>2P can promote <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> progression, suggesting it may be a clinically valuable biomarker and serve as a molecular target for the diagnosis, prognosis, and therapy of hepatocellular carcinoma.<\/jats:p>","DOI":"10.1002\/1878-0261.12553","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T11:03:48Z","timestamp":1564657428000},"page":"2246-2258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["RETRACTED: lnc<scp>RNA<\/scp>\u2010<scp>PDPK<\/scp>2P promotes hepatocellular carcinoma progression through the <scp>PDK<\/scp>1\/<scp>AKT<\/scp>\/Caspase 3 pathway"],"prefix":"10.1002","volume":"13","author":[{"given":"Weidong","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery the Second Affiliated Hospital of Nanchang University 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