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The long noncoding RNA (lncRNA) differentiation antagonizing non\u2010protein coding RNA (DANCR) exhibits oncogenic activity in several types of human cancers, including AML, but it remains unclear whether it regulates autophagy and chemoresistance in AML. We report here that cytarabine (Ara\u2010C) treatment elevates DANCR expression in human AML cells. In addition, DANCR overexpression confers and its knockdown diminishes Ara\u2010C resistance in human AML cells, suggesting that DANCR positively regulates AML chemoresistance to Ara\u2010C. Moreover, DANCR promotes autophagy in Ara\u2010C\u2010treated human AML cells and acts as a sponge to decrease miR\u201020a\u20105p expression, thereby upregulating the expression of ATG16L1, a critical component of the autophagy machinery. Importantly, ATG16L1 silencing abrogates DANCR\u2010promoted autophagy and markedly restores DANCR\u2010conferred Ara\u2010C resistance, suggesting that DANCR promotes MIR\u2010874\u20103P\/ATG16L1 axis\u2010regulated autophagy to confer Ara\u2010C resistance in human AML cells. Together, this study identifies DANCR as a positive regulator of Ara\u2010C resistance in human AML cells, suggesting this lncRNA as a potential target for overcoming Ara\u2010C resistance in AML chemotherapy.<\/jats:p>","DOI":"10.1002\/1878-0261.12661","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T10:36:00Z","timestamp":1583750160000},"page":"1203-1216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Long noncoding RNA DANCR confers cytarabine resistance in acute myeloid leukemia by activating autophagy <i>via<\/i> the miR\u2010874\u20103P\/ATG16L1 axis"],"prefix":"10.1002","volume":"15","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Jining Medical University 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