{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:15:14Z","timestamp":1788369314661,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","award":["00012093"],"award-info":[{"award-number":["00012093"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>Post\u2010transplant lymphoproliferative disorders (PTLD) and Burkitt's lymphoma (BL) are B\u2010cell malignancies strongly associated with Epstein\u2013Barr virus (EBV) infection. In these lymphoproliferative disorders, EBV infection induces an increase in the expression of the anti\u2010apoptotic protein BCL\u20102. Given its chemoprotective effect, BCL\u20102 constitutes an attractive target for new therapeutic strategies for EBV\u2010positive B\u2010cell malignancies. Here, we show that ABT\u2010737, a small inhibitor of BCL\u20102, BCL\u2010X(L), and BCL\u2010w, strongly induced apoptosis <jats:italic>in\u00a0vitro<\/jats:italic> in EBV\u2010positive lymphoblastoid cell lines (which is a model for PTLD), whereas BL was less sensitive. ABT\u2010737 reduced tumor growth and increased the overall survival of mice in a xenograft model of PTLD but had no effect on BL xenograft mice. ABT\u2010737 combined with a low dose of cyclophosphamide, a major component of the conventional CHOP chemotherapy regimen for BL patients, reduced tumor growth during treatment but failed to improve the overall survival of BL xenograft mice. By contrast, the combination of ABT\u2010737 and rituximab, one of the main options for the treatment of PTLD, was highly efficient and induced approximately 70% remission in PTLD xenograft mice. These results suggest that the use of agents targeting BCL\u20102, either alone or in combination with other conventional drugs, represents a novel promising approach for post\u2010transplant EBV\u2010positive B lymphoproliferative disorders.<\/jats:p>","DOI":"10.1002\/1878-0261.12759","type":"journal-article","created":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T03:54:27Z","timestamp":1593921267000},"page":"2520-2532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The BCL\u20102 family protein inhibitor ABT\u2010737 as an additional tool for the treatment of EBV\u2010associated post\u2010transplant lymphoproliferative disorders"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-4190","authenticated-orcid":false,"given":"Aude","family":"Robert","sequence":"first","affiliation":[{"name":"UMR 8126 CNRS Institut Gustave Roussy Universit\u00e9 Paris\u2010Saclay Villejuif 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