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MDS are associated with proinflammatory signaling, dysregulated immune response, and cell death in the bone marrow (BM). Aging, autoinflammation and autoimmunity are crucial features of disease progression, concordant with promoting growth of malignant clones and accumulation of mutations. <jats:italic>Suprabasin<\/jats:italic> (<jats:italic>SBSN<\/jats:italic>), a recently proposed proto\u2010oncogene of unknown function, physiologically expressed in stratified epithelia, is associated with poor prognosis of several human malignancies. Here, we showed that <jats:italic>SBSN<\/jats:italic> is expressed in the BM by myeloid cell subpopulations, including myeloid\u2010derived suppressor cells, and is secreted into BM plasma and peripheral blood of MDS patients. The highest expression of <jats:italic>SBSN<\/jats:italic> was present in a patient group with poor prognosis. <jats:italic>SBSN<\/jats:italic> levels in the BM correlated positively with blast percentage and negatively with CCL2 chemokine levels and lymphocyte count. <jats:italic>In\u00a0vitro<\/jats:italic> treatment of leukemic cells with interferon\u2010gamma and demethylating agent 5\u2010azacytidine (5\u2010AC) induced <jats:italic>SBSN<\/jats:italic> expression. This indicated that aberrant cytokine levels in the BM and epigenetic landscape modifications in MDS patients may underlie ectopic expression of <jats:italic>SBSN<\/jats:italic>. Our findings suggest SBSN as a candidate biomarker of high\u2010risk MDS with a possible role in disease progression and therapy resistance.<\/jats:p>","DOI":"10.1002\/1878-0261.12768","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T04:16:18Z","timestamp":1595391378000},"page":"2403-2419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes"],"prefix":"10.1002","volume":"14","author":[{"given":"Miroslav","family":"Pribyl","sequence":"first","affiliation":[{"name":"Department of Genome Integrity Institute of Molecular Genetics of the Czech Academy of Sciences Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sona","family":"Hubackova","sequence":"additional","affiliation":[{"name":"Department of Genome Integrity 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