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This is particularly true for high\u2010grade, advanced FIGO stage serous adenocarcinomas of the ovary (OC), fallopian tube (TC), and peritoneum (PC), which are currently all treated identically. We analyzed three independent patient cohorts using histopathologically classified diagnosis and various molecular approaches (transcriptomics, immunohistochemistry, next\u2010generation sequencing, fluorescent and chromogenic <jats:italic>in\u00a0situ<\/jats:italic> hybridization). Using multivariate Cox regression model, we found that PC is more aggressive compared with advanced\u2010stage OC independent of residual disease as shown by an earlier relapse\u2010free survival in two large cohorts (HR: 2.63, CI: 1.59\u20134.37, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, and HR: 1.66, CI: 1.04\u20132.63, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.033). In line with these findings, transcriptomic data revealed differentially expressed gene signatures identifying PC as high stromal response tumors. The third independent cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a04054) showed a distinction between these cancer types for markers suggested to be predictive for chemotherapy drug response. Our findings add additional evidence that ovarian and peritoneal cancers are epidemiologically and molecularly distinct diseases. Moreover, our data also suggest consideration of the tumor\u2010sampling site for future diagnosis and treatment decisions.<\/jats:p>","DOI":"10.1002\/1878-0261.12811","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T10:09:15Z","timestamp":1601892555000},"page":"91-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010grade serous peritoneal cancer follows a high stromal response signature and shows worse outcome than ovarian cancer"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-1942","authenticated-orcid":false,"given":"Francis","family":"Jacob","sequence":"first","affiliation":[{"name":"Ovarian Cancer Research Department of Biomedicine University Hospital Basel University of Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa 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