{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:03:58Z","timestamp":1789157038176,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870225"],"award-info":[{"award-number":["81870225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670416"],"award-info":[{"award-number":["81670416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060139"],"award-info":[{"award-number":["82060139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>\n                    Chronic kidney disease (CKD) is a common and complex disease in kidneys which has been associated with an increased risk of renal cell carcinoma. Elevated homocysteine (Hcy) levels are known to influence the development and progression of CKD by regulating podocyte injury and apoptosis. To investigate the molecular mechanisms triggered in podocytes by Hcy, we used\n                    <jats:italic>\n                      cbs\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice and observed that higher Hcy levels increased the apoptosis rate of podocytes with accompanying glomerular damage. Hcy\u2010induced podocyte injury and apoptosis in\n                    <jats:italic>\n                      cbs\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice was regulated by inhibition of microRNA (miR)\u20101929\u20105p expression. Overexpression of miR\u20101929\u20105p in podocytes inhibited apoptosis by upregulating Bcl\u20102. Furthermore, the expression of miR\u20101929\u20105p was regulated by epigenetic modifications of its promoter. Hcy upregulated DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2) levels, resulting in increased DNA methylation and H3K27me3 levels on the miR\u20101929\u20105p promoter. Additionally, we observed that\n                    <jats:italic>c\u2010Myc<\/jats:italic>\n                    recruited DNMT1 and EZH2 to the miR\u20101929\u20105p promoter and suppressed the expression of miR\u20101929\u20105p. In summary, we demonstrated that Hcy promotes podocyte apoptosis through the regulation of the epigenetic modifiers DNMT1 and EZH2, which are recruited by\n                    <jats:italic>c\u2010Myc<\/jats:italic>\n                    to the promoter of miR\u20101929\u20105p to silence miR\u20101929\u20105p expression.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13032","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T11:13:47Z","timestamp":1622459627000},"page":"3203-3221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Homocysteine induces podocyte apoptosis by regulating miR\u20101929\u20105p expression through\n                    <i>c\u2010Myc<\/i>\n                    , DNMT1 and EZH2"],"prefix":"10.1002","volume":"15","author":[{"given":"Lin","family":"Xie","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences Ningxia Medical 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