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In this study, we report that lipocalin 2 (LCN2), a small secreted glycoprotein belonging to the lipocalin superfamily, is expressed at significantly higher levels in IBC vs non\u2010IBC tumors, independently of molecular subtype. LCN2 levels were also significantly higher in IBC cell lines and in their culture media than in non\u2010IBC cell lines. High expression was associated with poor\u2010prognosis features and shorter overall survival in IBC patients. Depletion of LCN2 in IBC cell lines reduced colony formation, migration, and cancer stem cell populations\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    and inhibited tumor growth, skin invasion, and brain metastasis in mouse models of IBC. Analysis of our proteomics data showed reduced expression of proteins involved in cell cycle and DNA repair in LCN2\u2010silenced IBC cells. Our findings support that LCN2 promotes IBC tumor aggressiveness and offer a new potential therapeutic target for IBC.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13074","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T12:00:54Z","timestamp":1627992054000},"page":"2752-2765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-7013","authenticated-orcid":false,"given":"Emilly S.","family":"Villodre","sequence":"first","affiliation":[{"name":"Department of Breast Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"MD Anderson Morgan Welch Inflammatory Breast Cancer Clinic and Research Program The University of Texas MD Anderson Cancer Center Houston TX 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