{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:55:05Z","timestamp":1772117705269,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001729","name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n                    Prostate cancer is a heterogeneous disease with a need for new prognostic biomarkers. Human leukocyte antigen (HLA) genes are highly polymorphic genes central to antigen presentation to T\u2010cells. Two alleles, HLA\u2010A*02:01 and HLA\u2010A*24:02, have been associated with prognosis in patients diagnosed with\n                    <jats:italic>de novo<\/jats:italic>\n                    metastatic prostate cancer. We leveraged the next\u2010generation sequenced cohorts CPC\u2010GENE and TCGA\u2010PRAD to examine HLA alleles, antiviral T\u2010cell receptors and prostate cancer disease recurrence after prostatectomy. Carrying HLA\u2010A*02:01 (111\/229; 48% of patients) was independently associated with disease recurrence in patients with low\u2010intermediate risk prostate cancer. HLA\u2010A*11 (carried by 42\/441; 10% of patients) was independently associated with rapid disease recurrence in patients with high\u2010risk prostate cancer. Moreover, HLA\u2010A*02:01 carriers in which anti\u2010cytomegalovirus T\u2010cell receptors (CMV\u2010TCR) were identified in tumors (13\/144; 10% of all patients in the cohort) had a higher risk of disease recurrence than CMV\u2010TCR\u2010negative patients. These findings suggest that HLA\u2010type and CMV immunity may be valuable biomarkers for prostate cancer progression.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13273","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T02:46:35Z","timestamp":1655433995000},"page":"3452-3464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prostate cancer disease recurrence after radical prostatectomy is associated with\n                    <scp>HLA<\/scp>\n                    type and local cytomegalovirus immunity"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-7605","authenticated-orcid":false,"given":"Johanna","family":"Classon","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology Karolinska Institutet  Stockholm 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