{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:34:40Z","timestamp":1783625680889,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["CoG\u20102014\u2010646903"],"award-info":[{"award-number":["CoG\u20102014\u2010646903"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009093","name":"Fundaci\u00f3n Espa\u00f1ola de Hematolog\u00eda y Hemoterapia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002704","name":"Fundaci\u00f3n Cient\u00edfica Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","doi-asserted-by":"publisher","award":["INVES211226MOLI"],"award-info":[{"award-number":["INVES211226MOLI"]}],"id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002704","name":"Fundaci\u00f3n Cient\u00edfica Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","doi-asserted-by":"publisher","award":["INVES20011L\u00d3PE"],"award-info":[{"award-number":["INVES20011L\u00d3PE"]}],"id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FJC2019\u2010040868\u2010I"],"award-info":[{"award-number":["FJC2019\u2010040868\u2010I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015570","name":"Blood Cancer UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011104","name":"Universitat Aut\u00f2noma de Barcelona","doi-asserted-by":"publisher","award":["UAB\/CF\u2010180034"],"award-info":[{"award-number":["UAB\/CF\u2010180034"]}],"id":[{"id":"10.13039\/501100011104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017\/SGR\u2010503"],"award-info":[{"award-number":["2017\/SGR\u2010503"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>\n                    B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) is the commonest childhood cancer. High hyperdiploidy (HHD) identifies the most frequent cytogenetic subgroup in childhood B\u2010ALL. Although hyperdiploidy represents an important prognostic factor in childhood B\u2010ALL, the specific chromosome gains with prognostic value in HHD\u2010B\u2010ALL remain controversial, and the current knowledge about the hierarchy of chromosome gains, clonal heterogeneity and chromosomal instability in HHD\u2010B\u2010ALL remains very limited. We applied automated sequential\u2010iFISH coupled with single\u2010cell computational modeling to identify the specific chromosomal gains of the eight typically gained chromosomes in a large cohort of 72 primary diagnostic (DX,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200962) and matched relapse (REL,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) samples from HHD\u2010B\u2010ALL patients with either favorable or unfavorable clinical outcome in order to characterize the clonal heterogeneity, specific chromosome gains and clonal evolution. Our data show a high degree of clonal heterogeneity and a hierarchical order of chromosome gains in DX samples of HHD\u2010B\u2010ALL. The rates of specific chromosome gains and clonal heterogeneity found in DX samples differ between HHD\u2010B\u2010ALL patients with favorable or unfavorable clinical outcome. In fact, our comprehensive analyses at DX using a computationally defined risk predictor revealed low levels of trisomies +18+10 and low levels of clonal heterogeneity as robust relapse risk factors in minimal residual disease (MRD)\u2010negative childhood HHD\u2010B\u2010ALL patients: relapse\u2010free survival beyond 5\u2009years: 22.1% versus 87.9%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001 and 33.3% versus 80%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001, respectively. Moreover, longitudinal analysis of matched DX\u2010REL HHD\u2010B\u2010ALL samples revealed distinct patterns of clonal evolution at relapse. Our study offers a reliable prognostic sub\u2010stratification of pediatric MRD\u2010negative HHD\u2010B\u2010ALL patients.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13276","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T05:42:18Z","timestamp":1655790138000},"page":"2899-2919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high\u2010hyperdiploid B\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"16","author":[{"given":"Mireia","family":"Ramos\u2010Muntada","sequence":"first","affiliation":[{"name":"Cell Biology, Physiology and Immunology Department, Genetics of Male Fertility Group Universitat Aut\u00f2noma de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan L.","family":"Trincado","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, School of Medicine, Josep Carreras Leukemia Research Institute University of Barcelona  Spain"},{"name":"CNAG\u2010CRG, Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology (BIST)  Spain"},{"name":"Red Espa\u00f1ola de Ter\u00e1pias Avanzadas (TERAV) ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Blanco","sequence":"additional","affiliation":[{"name":"Cell Biology, Physiology and Immunology Department, Genetics of Male Fertility Group Universitat Aut\u00f2noma de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Bueno","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, School of Medicine, Josep Carreras Leukemia Research Institute University of Barcelona  Spain"},{"name":"Red Espa\u00f1ola de Ter\u00e1pias Avanzadas (TERAV) ISCIII  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBER\u2010ONC) ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia C.","family":"Rodr\u00edguez\u2010Cortez","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, School of Medicine, Josep Carreras Leukemia Research Institute University of Barcelona  Spain"},{"name":"Red Espa\u00f1ola de Ter\u00e1pias Avanzadas (TERAV) ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Bataller","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, School of Medicine, Josep Carreras Leukemia Research Institute University of Barcelona  Spain"},{"name":"Red Espa\u00f1ola de Ter\u00e1pias Avanzadas (TERAV) ISCIII  Barcelona Spain"},{"name":"Hematology Department, Hospital Cl\u00ednic de Barcelona, IDIBAPS University of Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"L\u00f3pez\u2010Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, School of Medicine, Josep Carreras Leukemia Research Institute University of Barcelona  Spain"},{"name":"Red Espa\u00f1ola de Ter\u00e1pias Avanzadas (TERAV) ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Schwab","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre Newcastle University  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Ortega","sequence":"additional","affiliation":[{"name":"Hematology Service, Experimental Hematology, Vall d'Hebr\u00f3n Institute of Oncology (VHIO) Vall d'Hebr\u00f3n Hospital Universitari  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Velasco","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology Department Vall d'Hebr\u00f3n Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Hospital Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Nomdedeu","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Hospital Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ram\u00edrez\u2010Orellana","sequence":"additional","affiliation":[{"name":"Hematology Diagnostic Laboratory Hospital Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Minguela","sequence":"additional","affiliation":[{"name":"Immunology Service Clinic University Hospital Virgen de la Arrixaca and Instituto Murciano de Investigaci\u00f3n Biom\u00e9dica (IMIB)  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Fuster","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Department Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB)  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Cuatrecasas","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Institut de Recerca Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Cam\u00f3s","sequence":"additional","affiliation":[{"name":"Hematology Laboratory, Hospital Sant Joan de D\u00e9u University of Barcelona  Spain"},{"name":"Leukemia and Other Pediatric Hemopathies, Developmental Tumor Biology Group Institut de Recerca Hospital Sant Joan de D\u00e9u Barcelona  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Ballerini","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Service d'H\u00e9matologie P\u00e9diatrique H\u00f4pital A. Trousseau  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Escherich","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Medical Center Hamburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Boer","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Oncode Institute  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"DenBoer","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Oncode Institute  Utrecht The Netherlands"},{"name":"Department of Pediatric Oncology\/Hematology Erasmus MC \u2013 Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas M.","family":"Hern\u00e1ndez\u2010Rivas","sequence":"additional","affiliation":[{"name":"Departamento de Hematolog\u00eda, Salamanca\u2010IBSAL Hospital Universitario de Salamanca  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Calasanz","sequence":"additional","affiliation":[{"name":"CIMA Lab Diagnostics Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cazzaniga","sequence":"additional","affiliation":[{"name":"Fondazione Tettamanti  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine J.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre Newcastle University  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Men\u00e9ndez","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, School of Medicine, Josep Carreras Leukemia Research Institute University of Barcelona  Spain"},{"name":"Red Espa\u00f1ola de Ter\u00e1pias Avanzadas (TERAV) ISCIII  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBER\u2010ONC) ISCIII  Barcelona Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7585-4519","authenticated-orcid":false,"given":"Oscar","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, School of Medicine, Josep Carreras Leukemia Research Institute University of Barcelona  Spain"},{"name":"Red Espa\u00f1ola de Ter\u00e1pias Avanzadas (TERAV) ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-378943"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.251"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01086"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.1636"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28748"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70580-6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110169"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.2.415.415"},{"key":"e_1_2_11_10_1","first-page":"213","article-title":"Heterogeneity of hyperdiploid (51\u201367) childhood acute lymphoblastic leukemia","volume":"10","author":"Raimondi SC","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.9.1876"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20671"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2018.02.012"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.12.3316.3316"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403673"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21011"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.085852"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70066-8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1128"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02668.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-051912"},{"key":"e_1_2_11_22_1","first-page":"313","article-title":"Impaired condensin complex and Aurora B kinase underlie mitotic and chromosomal defects in hyperdiploid B\u2010cell ALL","volume":"136","author":"Molina O","year":"2020","journal-title":"Blood"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05497.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2010.09.005"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1317-x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25217"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des431"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-7-76"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.1779"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13510"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syr066"},{"key":"e_1_2_11_32_1","first-page":"18","article-title":"Classification and regression by randomForest","volume":"2","author":"Liaw A","year":"2002","journal-title":"R News"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-213"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.161"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-024729"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.12.003"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0412"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0399-6"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2020.0028"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.027"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029611"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20451"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1104"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0971-7"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040824"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1861"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317042110"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2016.06.002"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-667378"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000053"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.13276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1878-0261.13276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.13276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:51:20Z","timestamp":1692694280000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.13276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,19]]},"references-count":49,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/1878-0261.13276"],"URL":"https:\/\/doi.org\/10.1002\/1878-0261.13276","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/1878-0261.13276\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13276\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13276\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13276\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13276\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13276\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13276\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13276\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13276\/v2\/review1","asserted-by":"object"}]},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,19]]},"assertion":[{"value":"2022-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}