{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:57:18Z","timestamp":1772117838027,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n                    Malignant pleural mesothelioma (MPM) is an aggressive cancer mainly related to asbestos exposure. Despite recent therapeutic advances, notably immunotherapies, the benefit remains limited and restricted to a small percentage of patients. Thus, a better understanding of the disease is needed to identify new therapeutic strategies. Recently, interleukin 7 receptor (IL\u20107R) has been described as being expressed by MPM cells and associated with poorer patient survival. Thus, the aim of this work was to study the IL\u20107R\/IL\u20107 pathway in MPM using patient samples. We found that, although more than 40% of MPM cells expressed IL\u20107R, IL\u20107 had no effect on their intracellular signaling. Accordingly, the addition of IL\u20107 to the culture medium did not affect MPM cell growth. Using The Cancer Genome Atlas (TCGA) database, we showed that high\n                    <jats:italic>IL7<\/jats:italic>\n                    gene expression in MPM tumors was associated with a higher overall patient survival and an induction of genes involved in the immune response. In pleural effusions (PEs), we found that IL\u20107 concentration was not a good diagnostic biomarker. However, we observed that high IL\u20107 levels in PEs were associated with shorter survival of MPM patients, but not of lung cancer patients. The prognostic value of IL\u20107 was also conserved when only patients with epithelioid mesothelioma, the most common histological type of MPM, were analyzed. Taken together, our study suggests that, although the IL\u20107R\/IL\u20107 signaling pathway is not functional in MPM cells, IL\u20107 expression in PEs may have prognostic value in MPM patients.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13310","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:09:05Z","timestamp":1661731745000},"page":"3606-3619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>IL<\/scp>\n                    \u20107 is expressed in malignant mesothelioma and has a prognostic value"],"prefix":"10.1002","volume":"16","author":[{"given":"Hoa\u2010Le","family":"Mai","sequence":"first","affiliation":[{"name":"CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064 Nantes Universit\u00e9  Nantes France"},{"name":"Immunology Graft Oncology Labex IGO  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Deshayes","sequence":"additional","affiliation":[{"name":"Immunology Graft Oncology Labex IGO  Nantes France"},{"name":"Nantes Universit\u00e9, Inserm UMR 1307, CNRS UMR 6075, Universit\u00e9 d'Angers CRCI2NA  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi\u2010Van\u2010Ha","family":"Nguyen","sequence":"additional","affiliation":[{"name":"CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064 Nantes Universit\u00e9  Nantes France"},{"name":"Immunology Graft Oncology Labex IGO  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Dehame","sequence":"additional","affiliation":[{"name":"Immunology Graft Oncology Labex IGO  Nantes France"},{"name":"Nantes Universit\u00e9, Inserm UMR 1307, CNRS UMR 6075, Universit\u00e9 d'Angers CRCI2NA  Nantes 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