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The aim of this study was to characterize and assess the role of ADAR\u2010dependent RNA editing in mesothelioma. We found that tumors and mesothelioma primary cultures have higher ADAR\u2010mediated RNA editing compared to mesothelial cells. Unsupervised clustering of editing in different genomic regions revealed heterogeneity between tumor samples as well as mesothelioma primary cultures. ADAR2 expression levels are higher in BRCA1\u2010associated protein 1 wild\u2010type tumors, with corresponding changes in RNA editing in transcripts and 3'UTR. ADAR2 knockdown and rescue models indicated a role in cell proliferation, altered cell cycle, increased sensitivity to antifolate treatment, and type\u20101 interferon signaling upregulation, leading to changes in the microenvironment\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    . 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