{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:07:26Z","timestamp":1784779646573,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK1871\u2010P5"],"award-info":[{"award-number":["GRK1871\u2010P5"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n                    Chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) has a high prevalence of up to 15% and accounts for 90\u201395% of prostatitis diagnoses, and yet its etiopathogenesis and link to prostate cancer (PCa) are still unclear. Here, we investigated microRNAs in exosomes isolated from blood and post\u2010prostatic\u2010massage urine of CP\/CPPS type IIIb patients and healthy men. THP\u20101 monocytes (human leukemia monocytic cell line) were treated with exosomes and subjected to mRNA arrays \u201cCancer Inflammation and Immunity Crosstalk\u201d and \u201cTranscription Factors.\u201d Using The Cancer Genome Atlas, the expression of CP\/CPPS\u2010associated microRNAs was analyzed in PCa and normal prostate tissue.\n                    <jats:italic>In\u2009silico<\/jats:italic>\n                    functional studies were carried out to explore the disease ontology of CP\/CPPS. In CP\/CPPS, urine exosomes exhibited significant upregulation of eight PCa\u2010specific microRNAs (e.g., hsa\u2010miR\u2010501, hsa\u2010miR\u201020a, and hsa\u2010miR\u2010106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis. In THP\u20101 monocytes, CP\/CPPS\u2010derived urine exosomes induced upregulation of PCa\u2010associated proinflammatory genes (e.g.,\n                    <jats:italic>CCR2<\/jats:italic>\n                    and\n                    <jats:italic>TLR2<\/jats:italic>\n                    ) and proto\u2010oncogene transcription factors (e.g.,\n                    <jats:italic>MYB<\/jats:italic>\n                    and\n                    <jats:italic>JUNB<\/jats:italic>\n                    ). In contrast, CP\/CPPS\u2010derived blood exosomes exhibited molecular properties similar to those of healthy men. Thus, CP\/CPPS exhibits molecular changes that constitute a risk for PCa and should be considered in the development of PCa biomarkers and cancer screening programs.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13329","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T02:20:20Z","timestamp":1667355620000},"page":"445-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Post\u2010prostatic\u2010massage urine exosomes of men with chronic prostatitis\/chronic pelvic pain syndrome carry prostate\u2010cancer\u2010typical micro\n                    <scp>RNA<\/scp>\n                    s and activate proto\u2010oncogenes"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2292-5819","authenticated-orcid":false,"given":"Laura","family":"Schneider","sequence":"first","affiliation":[{"name":"Clinic of Urology, Pediatric Urology and Andrology Justus\u2010Liebig\u2010University Giessen  Germany"},{"name":"Working Group \u201cEpigenetics of the Urogenital System,\u201d Clinic of Urology, Pediatric Urology and Andrology Justus\u2010Liebig\u2010University Giessen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temuujin","family":"Dansranjav","sequence":"additional","affiliation":[{"name":"Clinic of Urology, Pediatric Urology and Andrology Justus\u2010Liebig\u2010University Giessen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Campus Kerckhoff, Justus\u2010Liebig\u2010University of Giessen  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yan","sequence":"additional","affiliation":[{"name":"Clinic of Urology, Pediatric Urology and Andrology Justus\u2010Liebig\u2010University Giessen  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