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Altered protein modifications could also influence p53 function, even in the wild\u2010type protein. We assessed the impact of p53 protein phosphorylations on p53 functions as an alternative inactivation mechanism. We studied p53 phospho\u2010profiles induced by DNA\u2010damaging agents (fludarabine, doxorubicin) in 71\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010intact primary CLL samples. Doxorubicin induced two distinct phospho\u2010profiles: profile I (heavily phosphorylated) and profile II (hypophosphorylated). Profile II samples were less capable of activating p53 target genes upon doxorubicin exposure, resembling\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutant samples at the transcriptomic level, whereas standard p53 signaling was triggered in profile I.\n                    <jats:italic>ATM<\/jats:italic>\n                    locus defects were more common in profile II. The samples also differed in the basal activity of the hypoxia pathway: the highest level was detected in\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutant samples, followed by profile II and profile I. Our study suggests that wild\u2010type\n                    <jats:italic>TP53<\/jats:italic>\n                    CLL cells with less phosphorylated p53 show\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutant\u2010like behavior after DNA damage. p53 hypophosphorylation and the related lower ability to respond to DNA damage are linked to\n                    <jats:italic>ATM<\/jats:italic>\n                    locus defects and the higher basal activity of the hypoxia pathway.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13337","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T11:38:56Z","timestamp":1667648336000},"page":"82-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Distinct p53 phosphorylation patterns in chronic lymphocytic leukemia patients are reflected in the activation of circumjacent pathways upon\n                    <scp>DNA<\/scp>\n                    damage"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-9927","authenticated-orcid":false,"given":"Veronika","family":"Mancikova","sequence":"first","affiliation":[{"name":"Central European Institute of Technology (CEITEC) Masaryk University  Brno Czech Republic"},{"name":"Department of Internal Medicine \u2013 Hematology and Oncology, Faculty of Medicine Masaryk University and University Hospital Brno  Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Pesova","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology (CEITEC) Masaryk University  Brno Czech Republic"},{"name":"Department of Internal Medicine \u2013 Hematology and Oncology, Faculty of Medicine Masaryk University and University Hospital Brno  Czech 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