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The multifunctional oncoprotein Y\u2010box\u2010binding protein\u20101 (YB\u20101) is frequently overexpressed in cancer and its inhibition reduces aggressive behavior in multiple tumor types. Here, we investigated the effects of YB\u20101 on target gene regulation and PM cell behavior. Whereas siRNA\u2010mediated\n                    <jats:italic>YB\u20101<\/jats:italic>\n                    knockdown reduced cell motility,\n                    <jats:italic>YB\u20101<\/jats:italic>\n                    overexpression resulted in scattering, increased migration, and intravasation\n                    <jats:italic>in\u2009vitro<\/jats:italic>\n                    . Furthermore, YB\u20101 stimulated PM cell spreading in zebrafish. Combined knockdown and inducible overexpression of\n                    <jats:italic>YB\u20101<\/jats:italic>\n                    allowed bidirectional control and rescue of cell migration, the pattern of which was closely followed by the mRNA and protein levels of EGFR and the protein level of snail, whereas the mRNA levels of\n                    <jats:italic>MMP1<\/jats:italic>\n                    ,\n                    <jats:italic>EPHA5<\/jats:italic>\n                    , and\n                    <jats:italic>PARK2<\/jats:italic>\n                    showed partial regulation by YB\u20101. Finally, we identified snail as a critical regulator of YB\u20101\u2010mediated cell motility in PM. This study provides insights into the mechanism underlying the aggressive nature of PM and highlights the important role of YB\u20101 in this cancer. In this context, we found that YB\u20101 closely regulates EGFR and snail, and, moreover, that YB\u20101\u2010induced cell migration depends on snail.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13367","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:58:55Z","timestamp":1671757135000},"page":"815-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>YB<\/scp>\n                    \u20101 regulates mesothelioma cell migration via snail but not\n                    <scp>EGFR<\/scp>\n                    ,\n                    <scp>MMP1<\/scp>\n                    ,\n                    <scp>EPHA5<\/scp>\n                    or\n                    <scp>PARK2<\/scp>"],"prefix":"10.1002","volume":"18","author":[{"given":"Karin","family":"Schelch","sequence":"first","affiliation":[{"name":"Center for Cancer Research and Comprehensive Cancer Center Medical University of Vienna  Austria"},{"name":"Department of Thoracic Surgery Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Eder","sequence":"additional","affiliation":[{"name":"Center for Cancer Research and Comprehensive Cancer Center Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Zitta","sequence":"additional","affiliation":[{"name":"Center for Cancer Research and Comprehensive Cancer Center Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Phimmachanh","sequence":"additional","affiliation":[{"name":"Center for Cancer Research and Comprehensive Cancer Center Medical University of Vienna  Austria"},{"name":"University of Technology Sydney  NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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