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To interrogate the role of ABI1 in cancer development, we mapped the ABI1 interactome using proximity\u2010dependent labeling (PDL) with biotin followed by mass spectrometry. Using a novel PDL data filtering strategy, considering both peptide spectral matches and peak areas of detected peptides, we identified 212 ABI1 proximal interactors. These included WAVE2 complex components such as CYFIP1, NCKAP1, or WASF1, confirming the known role of ABI1 in the regulation of actin\u2010polymerization\u2010dependent processes. We also identified proteins associated with the TAK1\u2010IKK pathway, including TAK1, TAB2, and RIPK1, denoting a newly identified function of ABI1 in TAK1\u2010NF\u2010\u03baB inflammatory signaling. Functional assays using TNF\u03b1\u2010stimulated,\n                    <jats:italic>ABI1<\/jats:italic>\n                    \u2010overexpressing or\n                    <jats:italic>ABI1<\/jats:italic>\n                    \u2010deficient cells showed effects on the TAK1\u2010NF\u2010kB pathway\u2010dependent signaling to RIPK1, with\n                    <jats:italic>ABI1<\/jats:italic>\n                    \u2010knockout cells being less susceptible to TNF\u03b1\u2010induced, RIPK1\u2010mediated, TAK1\u2010dependent apoptosis. In sum, our PDL\u2010based strategy enabled mapping of the ABI1\u00a0proximal interactome, thus revealing a previously unknown role of this adaptor protein in TAK1\/RIPK1\u2010based regulation of cell death and survival.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13374","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:25:48Z","timestamp":1673569548000},"page":"2356-2379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Proximity proteomics reveals role of Abelson interactor 1 in the regulation of\n                    <scp>TAK1<\/scp>\n                    \/\n                    <scp>RIPK1<\/scp>\n                    signaling"],"prefix":"10.1002","volume":"17","author":[{"given":"Max","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Medicine, Alpert Medical School Brown University  Providence RI USA"},{"name":"Division of 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