{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:19:14Z","timestamp":1783955954555,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20427"],"award-info":[{"award-number":["U21A20427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY19H160003"],"award-info":[{"award-number":["LY19H160003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82073647"],"award-info":[{"award-number":["No.82073647"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82103914"],"award-info":[{"award-number":["No.82103914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    High\u2010grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer with 5\u2010year survival rates below 40%. Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is recommended for patients with advanced\u2010stage HGSOC unsuitable for primary debulking surgery (PDS). However, about 40% of patients receiving this treatment exhibited chemoresistance of uncertain molecular mechanisms and predictability. Here, we built a high\u2010quality ovary\u2010specific spectral library containing 130\u2009735 peptides and 10\u2009696 proteins on Orbitrap instruments. Compared to a published DIA pan\u2010human spectral library (DPHL), this spectral library provides 10% more ovary\u2010specific and 3% more ovary\u2010enriched proteins. This library was then applied to analyze data\u2010independent acquisition (DIA) data of tissue samples from an HGSOC cohort treated with NACT, leading to 10\u2009070 quantified proteins, which is 9.73% more than that with DPHL. We further established a six\u2010protein classifier by parallel reaction monitoring (PRM) to effectively predict the resistance to additional chemotherapy after IDS (Log\u2010rank test,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.002). The classifier was validated with 57 patients from an independent clinical center (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.014). Thus, we have developed an ovary\u2010specific spectral library for targeted proteome analysis, and propose a six\u2010protein classifier that could potentially predict chemoresistance in HGSOC patients after NACT\u2010IDS treatment.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13410","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:44:20Z","timestamp":1677631460000},"page":"1567-1580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Resistance prediction in high\u2010grade serous ovarian carcinoma with neoadjuvant chemotherapy using data\u2010independent acquisition proteomics and an ovary\u2010specific spectral library"],"prefix":"10.1002","volume":"17","author":[{"given":"Liujia","family":"Qian","sequence":"first","affiliation":[{"name":"School of Medicine Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5736-7397","authenticated-orcid":false,"given":"Jianqing","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)  Hangzhou China"},{"name":"Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangzhi","family":"Xue","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yue","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangang","family":"Gong","sequence":"additional","affiliation":[{"name":"The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)  Hangzhou China"},{"name":"Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjian","family":"Wang","sequence":"additional","affiliation":[{"name":"The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)  Hangzhou China"},{"name":"Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Ge","sequence":"additional","affiliation":[{"name":"Westlake Omics (Hangzhou) Biotechnology Co., Ltd.  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-4278","authenticated-orcid":false,"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)  Hangzhou China"},{"name":"Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-0802","authenticated-orcid":false,"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3869-7651","authenticated-orcid":false,"given":"Tiannan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Medicine Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences Westlake University  Hangzhou China"},{"name":"Institute of Basic Medical Sciences Westlake Institute for Advanced Study  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_10_4_1","unstructured":"ArmstrongDK SCP.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) Ovarian\u00a0Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer Version 3 NCCN (2022).2022. 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