{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:21:07Z","timestamp":1790742067063,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515110719"],"award-info":[{"award-number":["2020A1515110719"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103404"],"award-info":[{"award-number":["82103404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    Bacteria are the causative agents of various infectious diseases; however, the anti\u2010tumor effect of some bacterial species has attracted the attention of many scientists. The human oral cavity is inhabited by abundant and diverse bacterial communities and some of these bacterial communities could play a role in tumor suppression. Therefore, it is crucial to find oral bacterial species that show anti\u2010tumor activity on oral cancers. In the present study, we found that a high abundance of\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    , an anaerobic periodontal pathogen, in the tumor microenvironment (TME) was positively associated with the longer survival of patients with oral squamous cell carcinoma (OSCC). An\n                    <jats:italic>in vitro<\/jats:italic>\n                    assay confirmed that\n                    <jats:italic>P.\u2009gingivalis<\/jats:italic>\n                    accelerated the death of OSCC cells by inducing cell cycle arrest at the G2\/M phase, thus exerting its anti\u2010tumor effect. We also found that\n                    <jats:italic>P.\u2009gingivalis<\/jats:italic>\n                    significantly decreased tumor growth in a 4\u2010nitroquinoline\u20101\u2010oxide\u2010induced\n                    <jats:italic>in situ<\/jats:italic>\n                    OSCC mouse model. The transcriptomics data demonstrated that\n                    <jats:italic>P.\u2009gingivalis<\/jats:italic>\n                    suppressed the biosynthesis of mucin\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glycan and other\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glycans, as well as the expression of chemokines. Validation experiments further confirmed the downregulation of mucin\u20101 (MUC1) and C\u2010X\u2010C motif chemokine 17 (CXCL17) expression by\n                    <jats:italic>P.\u2009gingivalis<\/jats:italic>\n                    treatment. Flow cytometry analysis showed that\n                    <jats:italic>P.\u2009gingivalis<\/jats:italic>\n                    successfully reversed the immunosuppressive TME, thereby suppressing OSCC growth. In summary, the findings of the present study indicated that the rational use of\n                    <jats:italic>P.\u2009gingivalis<\/jats:italic>\n                    could serve as a promising therapeutic strategy for OSCC.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13517","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T19:54:03Z","timestamp":1693857243000},"page":"1174-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<i>Porphyromonas gingivalis<\/i>\n                    suppresses oral squamous cell carcinoma progression by inhibiting\n                    <i>MUC1<\/i>\n                    expression and remodeling the tumor microenvironment"],"prefix":"10.1002","volume":"18","author":[{"given":"Zhou","family":"Lan","sequence":"first","affiliation":[{"name":"Stomatological Hospital, School of Stomatology Southern Medical University  Guangzhou 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