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However, they are not effective against cancers with certain genetic alterations. A recent study by Mota et\u00a0al. focussed on understanding why ALK+ NSCLC cancers are immune cold and making them more receptive to ICIs using a vaccine\u2010based approach. The study highlighted cell\u2010specific differences in the presentation of immunogenic peptides and the location of tumours as factors in the poor immune response. Vaccines based on ALK peptides improved immune response, and when combined with ICIs, this led to a striking improvement in survival in a mouse model of ALK+ NSCLC.<\/jats:p>","DOI":"10.1002\/1878-0261.13533","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:26:36Z","timestamp":1696497996000},"page":"2218-2220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>ALKing<\/scp> the flames of lung cancer immunosensitivity"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0604-2773","authenticated-orcid":false,"given":"Richard","family":"Bayliss","sequence":"first","affiliation":[{"name":"School of Molecular and Cellular Biology, Faculty of Biological Sciences University of Leeds  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Sarnowska","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunotherapy Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Yeoh","sequence":"additional","affiliation":[{"name":"School of Molecular and Cellular Biology, Faculty of Biological Sciences University of Leeds  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephina","family":"Sampson","sequence":"additional","affiliation":[{"name":"School of Molecular and Cellular Biology, Faculty of Biological Sciences University of Leeds  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.877594"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-3101"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13446"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00591-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abi8800"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0089"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5947"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0380"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-251892"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21182"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.15238"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322892111"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31893"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-023-00350-7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0855"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.13533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T04:03:37Z","timestamp":1698897817000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.13533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/1878-0261.13533"],"URL":"https:\/\/doi.org\/10.1002\/1878-0261.13533","archive":["Portico"],"relation":{},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]},"assertion":[{"value":"2023-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}