{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:57:53Z","timestamp":1783367873334,"version":"3.54.6"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002943","name":"Departament d'Innovaci\u00f3, Universitats i Empresa, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021SGR00184"],"award-info":[{"award-number":["2021SGR00184"]}],"id":[{"id":"10.13039\/501100002943","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002943","name":"Departament d'Innovaci\u00f3, Universitats i Empresa, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017SGR449"],"award-info":[{"award-number":["2017SGR449"]}],"id":[{"id":"10.13039\/501100002943","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020\u2010117815RB\u2010100"],"award-info":[{"award-number":["PID2020\u2010117815RB\u2010100"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    High\u2010grade serous ovarian cancer (HGSOC) is the deadliest gynecological malignancy. The most common form of metastatic spread of HGSOC is transcoelomic dissemination. In this process, detached cells from the primary tumor aggregate as tumorspheres and promote the accumulation of peritoneal ascites. This represents an early event in HGSOC development and is indicative of poor prognosis. In this study, based on tumorspheres isolated from ascitic liquid samples from HGSOC patients, ovarian cancer spheroid 3D cultures, and\n                    <jats:italic>in\u2009vivo<\/jats:italic>\n                    models, we describe a key signal for tumorsphere formation in HGSOC. We report that platelet\u2010derived growth factor receptor beta (PDGFR\u03b2) is essential for fibronectin\u2010mediated cell clustering of ovarian cancer cells into tumorspheres. This effect is mediated by the kinase NUAK family SNF1\u2010like kinase 1 (NUAK1) and blocked by PDGFR\u03b2 pharmacological or genetic inhibition. In the absence of PDGFR\u03b2, ovarian cancer cells can be provided with fibronectin by cancer\u2010associated fibroblasts to generate chimeric spheroids. This work provides new insights that uncover potential targets to prevent peritoneal dissemination, the main cause of advanced disease in HGSOC patients.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13556","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T20:07:16Z","timestamp":1701115636000},"page":"136-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ovarian cancer relies on the\n                    <scp>PDGFR\u03b2<\/scp>\n                    \u2013fibronectin axis for tumorsphere formation and metastatic spread"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-3695","authenticated-orcid":false,"given":"N\u00faria","family":"Gendrau\u2010Sanclemente","sequence":"first","affiliation":[{"name":"Program Against Cancer Therapeutic Resistance (ProCURE) Catalan Institute of Oncology (ICO), Hospital Duran i Reynals  Barcelona Spain"},{"name":"Oncobell Program Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Figueras","sequence":"additional","affiliation":[{"name":"Program Against Cancer Therapeutic Resistance (ProCURE) Catalan Institute of Oncology (ICO), Hospital Duran i Reynals  Barcelona Spain"},{"name":"Oncobell Program Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Gracova","sequence":"additional","affiliation":[{"name":"Program Against Cancer Therapeutic Resistance (ProCURE) Catalan Institute of Oncology (ICO), Hospital Duran i Reynals  Barcelona Spain"},{"name":"Oncobell Program Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona 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Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"},{"name":"Department of Pathology University Hospital of Bellvitge (IDIBELL)  Barcelona Spain"},{"name":"CIBERONC Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Fernandez\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Gynaecology University Hospital of Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Barahona","sequence":"additional","affiliation":[{"name":"Department of Gynaecology University Hospital of Bellvitge (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lola","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Department of Gynaecology University Hospital of Bellvitge (IDIBELL)  Barcelona 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