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Up to 30% of cancer patients succumb directly to Ccx, yet therapies that effectively address this perturbed metabolic state are rare. In recent decades, several characteristics of Ccx have been established in mice and humans, of which we here highlight adipose tissue dysfunction, muscle wasting and systemic inflammation, as they are directly linked to biomarker discovery. To counteract cachexia pathogenesis as early as possible and mitigate its detrimental impact on anti\u2010cancer treatments, identification and validation of clinically endorsed biomarkers assume paramount importance. Ageing was recently shown to affect both the validity of Ccx biomarkers and Ccx development, but the underlying mechanisms are still unknown. Thus, unravelling the intricate interplay between ageing and Ccx can help to counteract Ccx pathogenesis and tailor diagnostic and treatment strategies to individual needs.<\/jats:p>","DOI":"10.1002\/1878-0261.13590","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T05:19:20Z","timestamp":1709097560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cancer cachexia: biomarkers and the influence of age"],"prefix":"10.1002","author":[{"given":"Julia","family":"Geppert","sequence":"first","affiliation":[{"name":"Institute for Diabetes and Cancer Helmholtz Munich  Neuherberg Germany"},{"name":"Joint Heidelberg\u2010IDC Translational Diabetes Program, Inner Medicine 1 Heidelberg University Hospital  Germany"},{"name":"German Center for Diabetes Research (DZD)  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3926-1534","authenticated-orcid":false,"given":"Maria","family":"Rohm","sequence":"additional","affiliation":[{"name":"Institute for Diabetes and Cancer Helmholtz Munich  Neuherberg Germany"},{"name":"Joint Heidelberg\u2010IDC Translational Diabetes Program, Inner Medicine 1 Heidelberg University Hospital  Germany"},{"name":"German Center for Diabetes Research (DZD)  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s43440-020-00179-y","article-title":"Altered glucose metabolism and insulin resistance in cancer\u2010induced cachexia: a sweet poison","volume":"73","author":"Masi T","year":"2021","journal-title":"Pharmacol Rep"},{"issue":"10","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/nm.4171","article-title":"An AMP\u2010activated protein kinase\u2010stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice","volume":"22","author":"Rohm M","year":"2016","journal-title":"Nat Med"},{"issue":"6","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/jcsm.12626","article-title":"High levels of modified ceramides are a defining feature of murine and human cancer cachexia","volume":"11","author":"Morigny P","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"8392","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0140-6736(84)91929-9","article-title":"Cancer cachexia and protein metabolism","volume":"1","author":"Jeevanandam M","year":"1984","journal-title":"Lancet"},{"issue":"2","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molmet.2015.11.004","article-title":"Ataxin\u201010 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia","volume":"5","author":"Sch\u00e4fer M","year":"2016","journal-title":"Mol Metab"},{"issue":"2","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon KC","year":"2012","journal-title":"Cell Metab"},{"issue":"4","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0149-2918(05)80001-3","article-title":"Prognostic effect of weight loss prior to chemotherapy in cancer patients. 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