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Therefore, new noninvasive biomarkers for CRC are required. Recent studies have revealed an imbalance in the oral and gut microbiomes of patients with CRC, as well as impaired gut vascular barrier function. In the present study, the microbiomes of saliva, crevicular fluid, feces, and non\u2010neoplastic and tumor intestinal tissue samples of 93 CRC patients and 30 healthy individuals without digestive disorders (non\u2010CRC) were analyzed by 16S rRNA metabarcoding procedures. The data revealed that\n                    <jats:italic>Parvimonas<\/jats:italic>\n                    ,\n                    <jats:italic>Fusobacterium<\/jats:italic>\n                    , and\n                    <jats:italic>Bacteroides fragilis<\/jats:italic>\n                    were significantly over\u2010represented in stool samples of CRC patients, whereas\n                    <jats:italic>Faecalibacterium<\/jats:italic>\n                    and\n                    <jats:italic>Blautia<\/jats:italic>\n                    were significantly over\u2010abundant in the non\u2010CRC group. Moreover, the tumor samples were enriched in well\u2010known periodontal anaerobes, including\n                    <jats:italic>Fusobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Parvimonas<\/jats:italic>\n                    ,\n                    <jats:italic>Peptostreptococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Porphyromonas<\/jats:italic>\n                    , and\n                    <jats:italic>Prevotella<\/jats:italic>\n                    . Co\u2010occurrence patterns of these oral microorganisms were observed in the subgingival pocket and in the tumor tissues of CRC patients, where they also correlated with other gut microbes, such as\n                    <jats:italic>Hungatella<\/jats:italic>\n                    . This study provides new evidence that oral pathobionts, normally located in subgingival pockets, can migrate to the colon and probably aggregate with aerobic bacteria, forming synergistic consortia. Furthermore, we suggest that the group composed of\n                    <jats:italic>Fusobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Parvimonas<\/jats:italic>\n                    ,\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    , and\n                    <jats:italic>Faecalibacterium<\/jats:italic>\n                    could be used to design an excellent noninvasive fecal test for the early diagnosis of CRC. The combination of these four genera would significantly improve the reliability of a discriminatory test with respect to others that use a single species as a unique CRC biomarker.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13604","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T03:45:01Z","timestamp":1708141501000},"page":"1093-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["The multispecies microbial cluster of\n                    <i>Fusobacterium<\/i>\n                    ,\n                    <i>Parvimonas<\/i>\n                    ,\n                    <i>Bacteroides<\/i>\n                    and\n                    <i>Faecalibacterium<\/i>\n                    as a precision biomarker for colorectal cancer diagnosis"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1238-2221","authenticated-orcid":false,"given":"Kelly","family":"Conde\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Microbiome and Health Group (meiGAbiome), Microbiology Research Group, Institute of Biomedical Research (INIBIC) \u2013 Interdisciplinary Center for Chemistry and Biology (CICA) \u2013 University of A Coru\u00f1a (UDC) \u2013 CIBER de Enfermedades Infecciosas (CIBERINFEC\u2010ISCIII), Servicio de Microbiolog\u00eda University Hospital of A Coru\u00f1a (CHUAC)  A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-5949","authenticated-orcid":false,"given":"Pablo","family":"Aja\u2010Macaya","sequence":"additional","affiliation":[{"name":"Microbiome and Health Group (meiGAbiome), Microbiology Research Group, Institute of Biomedical Research (INIBIC) \u2013 Interdisciplinary Center for Chemistry and 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