{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:55:59Z","timestamp":1772117759119,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    The effect of grainyhead\u2010like transcription factor 3 (GRHL3) on cancer development depends on the cancer subtypes as shown in tumor entities such as colorectal or oral squamous cell carcinomas. Here, we analyzed the subtype\u2010specific role of GRHL3 in bladder carcinogenesis, comparing common urothelial carcinoma (UC) with squamous bladder cancer (sq\u2010BLCA). We examined GRHL3 mRNA and protein expression in cohorts of patient samples, its prognostic role and its functional impact on tumorigeneses in different molecular and histopathological subtypes of bladder cancer. We showed for GRHL3 a reverse expression in squamous and urothelial bladder cancer subtypes. Stably GRHL3\n                    <jats:italic>\u2010<\/jats:italic>\n                    overexpressing EJ28, J82, and SCaBER\n                    <jats:italic>in vitro<\/jats:italic>\n                    models revealed a tumor\u2010suppressive function in squamous and an oncogenic role in the urothelial cancer cells affecting cell and colony growth, and migratory and invasive capacities. Transcriptomic profiling demonstrated highly subtype\u2010specific\n                    <jats:italic>GRHL3<\/jats:italic>\n                    \u2010regulated expression networks coined by the enrichment of genes involved in integrin\u2010mediated pathways. In SCaBER, loss of ras homolog family member A (RHOA) GTPase activity was demonstrated to be associated with co\u2010regulation of eukaryotic translation initiation factor 4E family member 3 (\n                    <jats:italic>EIF4E3<\/jats:italic>\n                    ), a potential tumor suppressor gene. Thus, our data provide for the first time a detailed insight into the role of the transcription factor\n                    <jats:italic>GRHL3<\/jats:italic>\n                    in different histopathological subtypes of bladder cancer.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13623","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T03:05:50Z","timestamp":1709348750000},"page":"1397-1416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual role of\n                    <scp>GRHL3<\/scp>\n                    in bladder carcinogenesis depending on histological subtypes"],"prefix":"10.1002","volume":"18","author":[{"given":"Franziska C.","family":"Lammert","sequence":"first","affiliation":[{"name":"Institute of Pathology, University Hospital RWTH Aachen University  Germany"},{"name":"Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD)  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