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The aim of this study was to investigate the potential of analyzing urine samples for the presence of urine tumor DNA (utDNA) to replace cystoscopy for surveillance of bladder cancer recurrence. In this longitudinal, prospective, and observational study, 47 patients were followed for recurrence for 2\u2009years, involving analysis of utDNA using the BladMetrix DNA methylation biomarker test at each cystoscopy. In total, utDNA was detected in 21\/23 recurrences (91% sensitivity), including 5\/5 T1, T2, and carcinoma <jats:italic>in situ<\/jats:italic> (CIS) tumors (100%) and 10\/12 Ta tumors (83%), with &lt;\u20091% false\u2010negative test results. Importantly, utDNA analysis showed the potential to reduce the number of cystoscopies by 55%, benefitting 79% of the patients. Eleven of 23 recurrences (48%) were detected earlier with utDNA than with cystoscopy, and distinct patterns of residual utDNA post\u2010surgery indicated minimal residual disease (MRD) or field effect in 6% and 15% of the patients, respectively. In conclusion, utDNA analysis shows high sensitivity to detect tumor recurrence, potential to reduce the number of cystoscopies, and promise to guide patient\u2010specific surveillance regimens.<\/jats:p>","DOI":"10.1002\/1878-0261.13639","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T06:19:21Z","timestamp":1715235561000},"page":"2684-2695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Distinct longitudinal patterns of urine tumor <scp>DNA<\/scp> in patients undergoing surveillance for bladder cancer"],"prefix":"10.1002","volume":"18","author":[{"given":"Hege Marie","family":"Vedeld","sequence":"first","affiliation":[{"name":"Department of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital Oslo University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-7091","authenticated-orcid":false,"given":"Heidi","family":"Pharo","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital Oslo University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Klara","family":"S\u00f8rb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Urology Oslo University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Brandt\u2010Winge","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital Oslo University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May\u2010Britt","family":"Five","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital Oslo University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Jeanmougin","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital Oslo University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-4803","authenticated-orcid":false,"given":"Per","family":"Guldberg","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Center  Copenhagen Denmark"},{"name":"Department of Cancer and Inflammation Research, Institute for Molecular Medicine University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Wahlqvist","sequence":"additional","affiliation":[{"name":"Department of Urology Oslo University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-9345","authenticated-orcid":false,"given":"Guro Elisabeth","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital Oslo University Hospital  Norway"},{"name":"Department of Biosciences, The Faculty of Mathematics and Natural Sciences University of Oslo  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"GLOBOCAN.Global Cancer Statistics 2020. 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