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It is becoming apparent that these adaptations underpin most of the traits that define a cancer cell's identity, including the ability to avoid immune surveillance, endure nutrient and oxygen restrictions, detach and migrate from their natural histological niche, and avert human\u2010made aggressions (i.e.<\/jats:italic>, therapy). In a recent study, Benichou and collaborators identify carbohydrate\u2010responsive element\u2010binding protein (ChREBP), a master regulator of physiological glucose metabolism, as an oncogene in hepatocellular carcinoma (HCC) development. Upregulation of ChREBP expression results in a self\u2010stimulatory loop interconnecting PI3K\/AKT signaling and glucose metabolism to feed fatty acid and nucleotide synthesis supporting tumorigenesis. Importantly, pharmacological inhibition of ChREBP activity quells in vivo<\/jats:italic> HCC tumor growth without causing systemic toxicity. This study identifies novel oncometabolic pathways and open up new avenues to improve the treatment of a deadly tumor.<\/jats:p>","DOI":"10.1002\/1878-0261.13669","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T01:38:47Z","timestamp":1717551527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sweet dreams could be made of this: carbohydrate\u2010responsive element\u2010binding protein (ChREBP<\/scp>) as a target for hepatocellular carcinoma therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0375-6236","authenticated-orcid":false,"given":"Maite G.","family":"Fern\u00e1ndez\u2010Barrena","sequence":"first","affiliation":[{"name":"Hepatology Laboratory, Solid Tumors Program, CIMA, CCUN University of Navarra Pamplona Spain"},{"name":"CIBERehd Instituto de Salud Carlos III Madrid Spain"},{"name":"Instituto de Investigaciones Sanitarias de Navarra IdiSNA Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-3557","authenticated-orcid":false,"given":"Mat\u00edas A.","family":"Avila","sequence":"additional","affiliation":[{"name":"Hepatology Laboratory, Solid Tumors Program, CIMA, CCUN University of Navarra Pamplona Spain"},{"name":"CIBERehd Instituto de Salud Carlos III Madrid Spain"},{"name":"Instituto de Investigaciones Sanitarias de Navarra IdiSNA Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41571\u2010023\u201000825\u20103"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CGH.2023.01.039"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CCELL.2024.01.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2023.116021"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.09.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010024\u201045548\u2010W"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMET.2017.07.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2010.12.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1489182"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41388\u2010023\u201002831\u20102"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13046\u2010017\u20100646\u20106"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2019.12.015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.11.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2021.759015"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.13669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T01:38:49Z","timestamp":1717551529000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.13669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":15,"alternative-id":["10.1002\/1878-0261.13669"],"URL":"https:\/\/doi.org\/10.1002\/1878-0261.13669","archive":["Portico"],"relation":{},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"2024-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1878-0261.13669"}}