{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T23:45:43Z","timestamp":1785714343236,"version":"3.56.0"},"reference-count":101,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["NFRP EIRA HT9425\u201023\u20101\u20100831"],"award-info":[{"award-number":["NFRP EIRA HT9425\u201023\u20101\u20100831"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["NFRP W81XWH\u201016\u20101\u20100220"],"award-info":[{"award-number":["NFRP W81XWH\u201016\u20101\u20100220"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 NS096402"],"award-info":[{"award-number":["R21 NS096402"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_PC_19037"],"award-info":[{"award-number":["MC_PC_19037"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/V009583\/1"],"award-info":[{"award-number":["MR\/V009583\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutation of the\n                    <jats:italic>NF1<\/jats:italic>\n                    gene that is associated with various symptoms, including the formation of benign tumors, called neurofibromas, within nerves. Drug treatments are currently limited. The mitogen\u2010activated protein kinase kinase (MEK) inhibitor selumetinib is used for a subset of plexiform neurofibromas (PNs) but is not always effective and can cause side effects. Therefore, there is a clear need to discover new drugs to target\n                    <jats:italic>NF1<\/jats:italic>\n                    \u2010deficient tumor cells. Using a\n                    <jats:italic>Drosophila<\/jats:italic>\n                    cell model of NF1, we performed synthetic lethal screens to identify novel drug targets. We identified 54 gene candidates, which were validated with variable dose analysis as a secondary screen. Pathways associated with five candidates could be targeted using existing drugs. Among these, chloroquine (CQ) and bafilomycin A1, known to target the autophagy pathway, showed the greatest potential for selectively killing\n                    <jats:italic>NF1<\/jats:italic>\n                    \u2010deficient\n                    <jats:italic>Drosophila<\/jats:italic>\n                    cells. When further investigating autophagy\u2010related genes, we found that 14 out of 30 genes tested had a synthetic lethal interaction with\n                    <jats:italic>NF1<\/jats:italic>\n                    . These 14 genes are involved in multiple aspects of the autophagy pathway and can be targeted with additional drugs that mediate the autophagy pathway, although CQ was the most effective. The lethal effect of autophagy inhibitors was conserved in a panel of human\n                    <jats:italic>NF1<\/jats:italic>\n                    \u2010deficient Schwann cell lines, highlighting their translational potential. The effect of CQ was also conserved in a\n                    <jats:italic>Drosophila NF1 in vivo<\/jats:italic>\n                    model and in a xenografted\n                    <jats:italic>NF1<\/jats:italic>\n                    \u2010deficient tumor cell line grown in mice, with CQ treatment resulting in a more significant reduction in tumor growth than selumetinib treatment. Furthermore, combined treatment with CQ and selumetinib resulted in a further reduction in\n                    <jats:italic>NF1<\/jats:italic>\n                    \u2010deficient cell viability. In conclusion,\n                    <jats:italic>NF1<\/jats:italic>\n                    \u2010deficient cells are vulnerable to disruption of the autophagy pathway. This pathway represents a promising target for the treatment of\n                    <jats:italic>NF1<\/jats:italic>\n                    \u2010associated tumors, and we identified CQ as a candidate drug for the treatment of\n                    <jats:italic>NF1<\/jats:italic>\n                    tumors.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.13704","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T02:54:35Z","timestamp":1723431275000},"page":"825-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors"],"prefix":"10.1002","volume":"19","author":[{"given":"Megan","family":"Stevens","sequence":"first","affiliation":[{"name":"Living Systems Institute University of Exeter  UK"},{"name":"Department of Clinical and Biomedical Science University of Exeter  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Wang","sequence":"additional","affiliation":[{"name":"Living Systems Institute University of Exeter  UK"},{"name":"The First People's Hospital of Qinzhou  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0785-0860","authenticated-orcid":false,"given":"Stephanie J.","family":"Bouley","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1795-8242","authenticated-orcid":false,"given":"Torrey R.","family":"Mandigo","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Living Systems Institute University of Exeter  UK"},{"name":"Department of Clinical and Biomedical Science University of Exeter  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Housden","sequence":"additional","affiliation":[{"name":"Living Systems Institute University of Exeter  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Perrimon","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute Harvard Medical School  Boston MA USA"},{"name":"Howard Hughes Medical Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-698X","authenticated-orcid":false,"given":"James A.","family":"Walker","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine Massachusetts General Hospital  Boston MA USA"},{"name":"Cancer Program Broad Institute of MIT and Harvard  Cambridge MA USA"},{"name":"Department of Neurology, Massachusetts General Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9134-4279","authenticated-orcid":false,"given":"Benjamin E.","family":"Housden","sequence":"additional","affiliation":[{"name":"Living Systems Institute University of Exeter  UK"},{"name":"Department of Clinical and Biomedical Science University of Exeter  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33139"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.144"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/320121"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90150-D"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90149-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.16.030193.001151"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3911"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.06.009"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912735"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.2015.000802"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2016.01.012"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02530-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/10600280211046298"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1691"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7344"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2018.08.003"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.09.013"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aay0482"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aab3729"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.88"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.2119"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247005"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713362114"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3112"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24505-x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5313.791"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318481110"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1466806"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05954"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-8-r70"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001809"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05280"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.09.010"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/235050a0"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01846-19"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.53"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C114.627778"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140889"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.32229"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29900-x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1511503"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1929-y"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1066957"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.04.011"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.07.164"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.78386"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008920"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107856"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.014"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003958"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002281"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11133"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01331-x"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085771"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10846"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1221-6"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2012.184"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9048"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642565"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.05.010"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201912098"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2012.11.004"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1854"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06639"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.5.15066"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/45257"},{"key":"e_1_2_11_71_1","unstructured":"Enzalutamide. Bethesda (MD) National Institute of Diabetes and Digestive and Kidney Diseases LiverTox: Clinical and Research Information on Drug\u2010Induced Liver Injury.https:\/\/wwwncbinlmnihgov\/books\/NBK548070\/2012."},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1730"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.034"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5851"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03774-1"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00893.x"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00585-z"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.297"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2438"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1775"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2016311"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.32135"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc969"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207539"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.048"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.11888"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp235"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.138958"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2804"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.9.FOCUS14504"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.12.044"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13045"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.196"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.4161\/15548627.2014.981788"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29961"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03802-9"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119135"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.129"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515617113"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7342"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0367-9"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"}],"updated-by":[{"DOI":"10.1002\/1878-0261.70162","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000}}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.13704","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.13704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T01:19:29Z","timestamp":1741569569000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.13704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,11]]},"references-count":101,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/1878-0261.13704"],"URL":"https:\/\/doi.org\/10.1002\/1878-0261.13704","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/1878-0261.13704\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13704\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13704\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13704\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13704\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13704\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13704\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13704\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.13704\/v2\/decision1","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.20.473481","asserted-by":"object"}]},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,11]]},"assertion":[{"value":"2023-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}