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We reported that such cell subtypes are traceable in liquid biopsies through representative transcripts. Expanding on this concept, we included 57 genes representing cell subtypes, drug targets and relevant to resistance as non\u2010invasive biomarkers for stratification. This panel was tested by RT\u2010qPCR (quantitative reverse transcription polymerase chain reaction) in blood of controls and different categories of PCa patients. Overall, circulating transcripts showed predictive value throughout the disease. Those with aggressive pathological features such as intra\u2010ductal carcinoma at diagnosis showed more genes over\u2010expressed. In metastatic patients, signatures of subtypes or resistance were associated with treatments, progression\u2010free survival and overall survival. Altogether, testing markers of cell diversity, an intrinsic feature of tumours, and drug targets via liquid biopsies represents a valuable means to stratify patients and predict responses to current or new therapeutic modalities. Over\u2010expressed drug target genes suggest potential benefit from targeted treatments, justifying new clinical trials to offer patient\u2010tailored strategies to eventually impact on PCa mortality.<\/jats:p>","DOI":"10.1002\/1878-0261.13805","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T04:57:10Z","timestamp":1737521830000},"page":"1310-1331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical significance of stratifying prostate cancer patients through specific circulating genes"],"prefix":"10.1002","volume":"19","author":[{"given":"Seta","family":"Derderian","sequence":"first","affiliation":[{"name":"Urologic Oncology Research Group, Cancer Research Program Research Institute of the McGill University Health Center  Montreal Canada"},{"name":"Department of Surgery (Urology Division) McGill University  Montreal 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