{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:55:58Z","timestamp":1772117758707,"version":"3.50.1"},"reference-count":147,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF125"],"award-info":[{"award-number":["DNRF125"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013276","name":"Interreg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Acute lymphoblastic leukemia (ALL), the most common cancer in children, is overall divided into two subtypes, B\u2010cell precursor ALL (B\u2010ALL) and T\u2010cell ALL (T\u2010ALL), which have different molecular characteristics. Despite massive progress in understanding the disease trajectories of ALL, ALL remains a major cause of death in children. Thus, further research exploring the biological foundations of ALL is essential. Here, we examined the diagnostic, prognostic, and therapeutic potential of gene expression data in pediatric patients with ALL. We discovered a subset of expression markers differentiating B\u2010 and T\u2010ALL:\n                    <jats:italic>CCN2<\/jats:italic>\n                    ,\n                    <jats:italic>VPREB3<\/jats:italic>\n                    ,\n                    <jats:italic>NDST3<\/jats:italic>\n                    ,\n                    <jats:italic>EBF1<\/jats:italic>\n                    , RN7SKP185, RN7SKP291, SNORA73B, RN7SKP255, SNORA74A, RN7SKP48, RN7SKP80, LINC00114, a novel gene (ENSG00000227706), and 7SK. The expression level of these markers all demonstrated significant effects on patient survival, comparing the two subtypes. We also discovered four expression subgroups in the expression data with eight genes driving separation between two of these predicted subgroups. A subset of the 14 markers could distinguish B\u2010 and T\u2010ALL in an independent cohort of patients with ALL. This study can enhance our knowledge of the transcriptomic profile of different ALL subtypes.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70046","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T16:52:56Z","timestamp":1754931176000},"page":"3548-3577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Data\u2010driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes"],"prefix":"10.1002","volume":"19","author":[{"given":"Mona","family":"Nourbakhsh","sequence":"first","affiliation":[{"name":"Cancer Systems Biology, Section for Bioinformatics, Department of Health Technology Technical University of Denmark  Lyngby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Tom","sequence":"additional","affiliation":[{"name":"Cancer Systems Biology, Section for Bioinformatics, Department of 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