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Previously, we showed that ovarian cancer cell apoptosis can be triggered by inhibiting the anti\u2010apoptotic proteins Bcl\u2010x\n                    <jats:sub>L<\/jats:sub>\n                    and Mcl\u20101 and\/or by inducing their pro\u2010apoptotic partners Bim, Puma, and Noxa. The expression of these pro\u2010apoptotic proteins can be hindered by excessive histone deacetylation, resulting from HDAC overexpression. This study aimed to evaluate whether belinostat, an FDA\u2010approved pan\u2010HDAC inhibitor, could increase Bim, Puma, and\/or Noxa expression and induce ovarian cancer cell death, either alone or in combination with strategies targeting Bcl\u2010x\n                    <jats:sub>L<\/jats:sub>\n                    or Mcl\u20101. Belinostat exerted a cytostatic effect and, at higher concentrations, an apoptotic effect in SKOV3 and IGROV1\u2010R10 ovarian cancer cells. It induced a concentration\u2010dependent increase in Bim, Puma, and Noxa protein expression, while partially repressing that of Bcl\u2010x\n                    <jats:sub>L<\/jats:sub>\n                    . Inhibition of Bcl\u2010x\n                    <jats:sub>L<\/jats:sub>\n                    sensitized both cell lines to belinostat, as did inhibition of Mcl\u20101 in IGROV1\u2010R10 cells. Interestingly, belinostat's anticancer activity was also enhanced by inhibitors of Bcl\u2010x\n                    <jats:sub>L<\/jats:sub>\n                    or Mcl\u20101 in patient\u2010derived tumor organoids. This study therefore positions belinostat\u2010based strategies as promising therapies for ovarian cancer.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70050","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T08:25:01Z","timestamp":1749371101000},"page":"3325-3341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The anticancer effect of the\n                    <scp>HDAC<\/scp>\n                    inhibitor belinostat is enhanced by inhibitors of Bcl\u2010\n                    <scp>\n                      x\n                      <sub>L<\/sub>\n                    <\/scp>\n                    or Mcl\u20101 in ovarian cancer"],"prefix":"10.1002","volume":"19","author":[{"given":"C\u00e9cilia","family":"Thomine","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and 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