{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:47:05Z","timestamp":1784209625885,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    While radioactive iodine therapy (RAIT) has been an effective treatment for thyroid cancer, its link to clonal hematopoiesis (CH) has been yet underexplored. In this study, error\u2010corrected sequencing (median depth: 1926\u00d7) of 93 CH\u2010related genes was performed from the blood samples of 358 thyroid cancer patients, including 110 controls (no RAIT) and 248 RAIT recipients. RAIT recipients were stratified into low\u2010 and high\u2010dose groups using a 7.4\u2009GBq cutoff. Multivariable logistic regression revealed that the high\u2010dose group had a higher CH prevalence with variant allele frequency (VAF) higher than 2% compared to controls, especially in patients aged \u226550 (OR\u2009=\u20092.44, CI\u2009=\u20091.04\u20136.00,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.04). Thirteen genes had mutations with VAF\u2009&gt;2%, with\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    ,\n                    <jats:italic>TET2<\/jats:italic>\n                    , and\n                    <jats:italic>PPM1D<\/jats:italic>\n                    being the most common. Notably, only the\n                    <jats:italic>PPM1D<\/jats:italic>\n                    mutations were significantly linked to RAIT, occurring more frequently in the high\u2010dose group (13%) compared to the low\u2010dose group (5%) or controls (2%) at a VAF cutoff of 0.5%. In silico analyses indicated that truncating\n                    <jats:italic>PPM1D<\/jats:italic>\n                    mutations confer a selective advantage under high\u2010dose RAIT and with older age. Although the prognostic implications of\n                    <jats:italic>PPM1D<\/jats:italic>\n                    \u2010mutated CH remain to be further elucidated, these findings offer valuable insights for optimizing RAIT dosing in thyroid cancer patients.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70078","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:54:07Z","timestamp":1750942447000},"page":"3079-3095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of high\u2010dose radioactive iodine therapy with\n                    <scp>PPM1D<\/scp>\n                    \u2010mutated clonal hematopoiesis in older individuals"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5382-9830","authenticated-orcid":false,"given":"Jaeryuk","family":"Kim","sequence":"first","affiliation":[{"name":"Genomic Medicine Institute, Medical Research Center Seoul National University  Seoul Korea"},{"name":"Department of Biomedical Sciences Seoul National University Graduate School  Seoul Korea"},{"name":"Department of Biochemistry and Molecular Biology Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Laboratory Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwoo","family":"Bae","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Medical Research Center Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeyong","family":"Choi","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Medical Research Center Seoul National University  Seoul Korea"},{"name":"Department of Biomedical Sciences Seoul National University Graduate School  Seoul Korea"},{"name":"Department of Biochemistry and Molecular Biology Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Biochemistry and Molecular Biology Kangwon National University School of Medicine  Gangwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun\u2010Wha","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Kangwon National University School of Medicine  Gangwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bukyoung","family":"Cha","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Medical Research Center Seoul National University  Seoul Korea"},{"name":"Department of Biochemistry and Molecular Biology Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeongseo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Wook","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eul\u2010Ju","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ah","family":"Lee","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Medical Research Center Seoul National University  Seoul Korea"},{"name":"Department of Pediatrics Seoul National University Children's Hospital, Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-9342","authenticated-orcid":false,"given":"Jin Chul","family":"Paeng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-6364","authenticated-orcid":false,"given":"Young Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Medical Research Center Seoul National University  Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology Seoul National University  Seoul 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