{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:47:51Z","timestamp":1778575671121,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Prostate cancer is a prevalent tumor type that, despite being highly curable, progresses to metastatic disease in a fraction of patients, thus accounting for more than 350\u2009000 annual deaths worldwide. In turn, uncovering the molecular insights of metastatic disease is instrumental in improving the survival rate of prostate cancer patients. By means of gene expression meta\u2010analysis in multiple prostate cancer patient cohorts, we identified a set of genes that are differentially expressed in aggressive prostate cancer.\n                    <jats:italic>Transcription factor 19 (TCF19)<\/jats:italic>\n                    stood out as an unprecedented epithelial gene upregulated in metastatic disease, with prognostic potential and negatively associated with the activity of the androgen receptor. By combining computational and empirical approaches, our data revealed that TCF19 is required for full metastatic capacity, and its depletion influences core cancer\u2010related processes, such as tumor growth and vascular permeability, supporting the role of this gene in the dissemination of prostate tumor cells.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70118","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T16:42:03Z","timestamp":1757954523000},"page":"3634-3650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A bioinformatics screen identifies\n                    <scp>TCF19<\/scp>\n                    as an aggressiveness\u2010sustaining gene in prostate 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