{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:29:29Z","timestamp":1763454569320,"version":"3.45.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA008748\u201059"],"award-info":[{"award-number":["P30CA008748\u201059"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Medulloblastoma (MB) is the most common malignant tumor in the central nervous system in childhood and regularly metastasizes to the leptomeninges following radiation therapy. Using patient\u2010derived medulloblastoma models and genetically engineered mouse models, N\u00f6r\n                    <jats:italic>et\u00a0al.<\/jats:italic>\n                    observed enhanced inflammation and infiltration of myeloid cells within the brain following irradiation. The authors identified inflammatory cytokines and the resulting breakdown of blood\u2013brain barriers as the main culprits of MB leptomeningeal metastasis. This study demonstrated that targeting inflammation through the use of dexamethasone effectively reduced systemic inflammatory cytokines and the resulting radiation\u2010induced leptomeningeal metastasis.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70125","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:54:27Z","timestamp":1758045267000},"page":"2761-2763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Only the strong survive: therapeutic selective pressure drives medulloblastoma leptomeningeal metastasis"],"prefix":"10.1002","volume":"19","author":[{"given":"Francis Y.","family":"He","sequence":"first","affiliation":[{"name":"Neuroscience Program, Graduate School of Biomedical Science Weill Cornell Medicine  New York USA"},{"name":"Human Oncology &amp; Pathogenesis Program Memorial Sloan Kettering Cancer Center  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-1248","authenticated-orcid":false,"given":"Adrienne","family":"Boire","sequence":"additional","affiliation":[{"name":"Human Oncology &amp; Pathogenesis Program Memorial Sloan Kettering Cancer Center  New York USA"},{"name":"Department of Neurology Memorial Sloan Kettering Cancer Center  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.7842"},{"key":"e_1_2_6_3_1","article-title":"Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process","volume":"1534","author":"N\u00f6r C","year":"2025","journal-title":"Dev Cell"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.038"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn0478"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7377"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0340-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16478"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10825"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.3290"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01706"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.70125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:24:47Z","timestamp":1763454287000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.70125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/1878-0261.70125"],"URL":"https:\/\/doi.org\/10.1002\/1878-0261.70125","archive":["Portico"],"relation":{},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"type":"print","value":"1574-7891"},{"type":"electronic","value":"1878-0261"}],"subject":[],"published":{"date-parts":[[2025,9,16]]},"assertion":[{"value":"2025-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}