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Among them, large\u2010conductance calcium\u2010activated potassium (BK\n                    <jats:sub>Ca<\/jats:sub>\n                    ) channels play a pivotal role in both normal brain physiology and the pathogenesis of glioblastoma multiforme, a highly aggressive primary brain tumor. Within the central nervous system, BK\n                    <jats:sub>Ca<\/jats:sub>\n                    channels are widely expressed in neurons, astrocytes, and oligodendrocytes, contributing to ion homeostasis and synaptic transmission. In glioblastoma cells, overexpression of BK\n                    <jats:sub>Ca<\/jats:sub>\n                    channels, particularly the glioma\u2010specific gBK\n                    <jats:sub>Ca<\/jats:sub>\n                    variant, facilitates tumor progression by enhancing cell migration, invasion, and therapeutic resistance. Recent evidence highlights the significance of the mitochondrial isoform of the BK\n                    <jats:sub>Ca<\/jats:sub>\n                    channel (mitoBK\n                    <jats:sub>Ca<\/jats:sub>\n                    ) in modulating oxidative phosphorylation and reactive oxygen species generation, thereby promoting tumor cell survival under hypoxic and cytotoxic stress. This review summarizes current insights into the role of BK\n                    <jats:sub>Ca<\/jats:sub>\n                    and mitoBK\n                    <jats:sub>Ca<\/jats:sub>\n                    channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BK\n                    <jats:sub>Ca<\/jats:sub>\n                    \u2010directed therapies for glioblastoma treatment.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70167","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T09:15:21Z","timestamp":1764926121000},"page":"1398-1419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential therapeutic targeting of BK\n                    <sub>Ca<\/sub>\n                    channels in glioblastoma treatment"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-199X","authenticated-orcid":false,"given":"Kamila","family":"Maliszewska\u2010Olejniczak","sequence":"first","affiliation":[{"name":"Department of Physics and Biophysics Institute of Biology, Warsaw University of Life Sciences \u2013 SGGW  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Pytlak","sequence":"additional","affiliation":[{"name":"Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Jaworowska","sequence":"additional","affiliation":[{"name":"Department of Physics and Biophysics Institute of Biology, Warsaw University of Life Sciences \u2013 SGGW  Warsaw 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