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This study evaluates the efficacy of the Wnt\/\n                    <jats:italic>CTNNB1<\/jats:italic>\n                    inhibitor WNTinib as a potential HB treatment, since\n                    <jats:italic>CTNNB1<\/jats:italic>\n                    mutations occur in 70\u201390% of HBs. WNTinib's efficacy was assessed in three animal models (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200948): (a) patient\u2010derived xenograft (PDX) HB tumors (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095\n                    <jats:italic>CTNNB1\u2010<\/jats:italic>\n                    mutant,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091\n                    <jats:italic>CTNNB1<\/jats:italic>\n                    wild\u2010type) implanted in NSG mice; (b) PDX\u2010derived TT001\u2010 and (c) HepG2\u2010HB cells subcutaneously implanted in Fox1\n                    <jats:sup>nu<\/jats:sup>\n                    mice; and in two patient\u2010derived organoids from\n                    <jats:italic>CTNNB1<\/jats:italic>\n                    \u2010mutant HBs. WNTinib delayed tumor growth in\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094\/5\n                    <jats:italic>CTNNB1<\/jats:italic>\n                    \u2010mutant PDX models and significantly improved survival versus controls (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.03), with no effect in the wild\u2010type model. Further, in the TT001 and HepG2 models, WNTinib reduced tumor growth (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05 and\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002) and extended survival (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.03 and\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.008), respectively. In HB organoids, WNTinib demonstrated greater efficacy than standard\u2010of\u2010care cisplatin (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.009, org\u20101), and its antitumor effect was further enhanced when combined with chemotherapy (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01, org\u20101;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.007, org\u201022). WNTinib delays tumor progression and increases survival in\n                    <jats:italic>CTNNB1<\/jats:italic>\n                    \u2010mutated HB models, providing rationale to explore its use in human HB.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70168","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T17:40:48Z","timestamp":1765215648000},"page":"920-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effective therapeutic targeting of\n                    <i>CTNNB1<\/i>\n                    \u2010mutant hepatoblastoma with\n                    <scp>WNTinib<\/scp>"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4256-4336","authenticated-orcid":false,"given":"Ugne","family":"Balaseviciute","sequence":"first","affiliation":[{"name":"Liver Cancer Translational Research Group, Institut d'Investigacions Biom\u00e8diques 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(Divisions of Liver Diseases, Department of Hematology\/Oncology, Department of Medicine, Department of Pathology) Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-4052","authenticated-orcid":false,"given":"Jordi","family":"Abril\u2010Fornaguera","sequence":"additional","affiliation":[{"name":"Liver Cancer Translational Research Group, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Cl\u00ednic Universitat de Barcelona  Catalonia Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Catalonia Spain"},{"name":"Mount Sinai Liver Cancer Program (Divisions of Liver Diseases, Department of Hematology\/Oncology, Department of Medicine, Department of Pathology) Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai  New York NY 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OncoGenomics and Innovative Therapeutics Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai  New York NY USA"},{"name":"The Precision Immunology Institute Icahn School of Medicine at Mount Sinai  New York NY USA"},{"name":"Bioinformatics for Next Generation Sequencing Shared Resource Facility Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0288-6314","authenticated-orcid":false,"given":"Roser","family":"Pinyol","sequence":"additional","affiliation":[{"name":"Liver Cancer Translational Research Group, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Cl\u00ednic Universitat de Barcelona  Catalonia Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Catalonia 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