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Despite distinct prognoses and clinical outcomes between its main histological subtypes, squamous cell carcinoma (SCC) and adenocarcinoma (ADC), current treatment regimens remain largely similar, creating an urgent need for targeted therapeutic strategies based on molecular distinctions. To address this gap, the long noncoding RNA\n                    <jats:italic>IGFL2\u2010AS1<\/jats:italic>\n                    was investigated as a potential prognostic biomarker and therapeutic target in cervical adenocarcinoma. A translational approach was employed that integrated patient transcriptome data,\n                    <jats:italic>in silico<\/jats:italic>\n                    analysis from public databases, and\n                    <jats:italic>in vitro<\/jats:italic>\n                    validation. Using CRISPR\/dCas9 technology,\n                    <jats:italic>IGFL2\u2010AS1<\/jats:italic>\n                    expression was modulated in HeLa (ADC) and SiHa (SCC) cell lines to assess its impact on cellular characteristics associated with tumorigenesis.\n                    <jats:italic>In silico<\/jats:italic>\n                    analysis revealed that\n                    <jats:italic>IGFL2\u2010AS1<\/jats:italic>\n                    expression was significantly reduced in ADC compared to SCC, and its low expression was consistently linked to poorer ADC prognosis and decreased patient survival. Notably, overexpression of\n                    <jats:italic>IGFL2\u2010AS1<\/jats:italic>\n                    in HeLa cells significantly reduced cell proliferation, migration, clonogenic survival, and enhanced sensitivity to cisplatin and doxorubicin. Conversely,\n                    <jats:italic>IGFL2\u2010AS1<\/jats:italic>\n                    repression in SiHa cells yielded no significant phenotypic changes, suggesting a context\u2010dependent mechanism.\n                    <jats:italic>IGFL2\u2010AS1<\/jats:italic>\n                    is identified as a histological subtype\u2010specific prognostic biomarker and promising therapeutic target for cervical adenocarcinoma.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70217","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:54:53Z","timestamp":1770112493000},"page":"1643-1660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeted modulation of\n                    <i>IGFL2\u2010AS1<\/i>\n                    reveals its translational potential in cervical 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