{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:45:25Z","timestamp":1787244325441,"version":"build-2736575974"},"reference-count":114,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["ARCDOC42022020004746"],"award-info":[{"award-number":["ARCDOC42022020004746"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u2010DualmAb https:\/\/ror.org\/00rbzpz17"],"award-info":[{"award-number":["ANR\u2010DualmAb https:\/\/ror.org\/00rbzpz17"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023437","name":"Advanced Remanufacturing and Technology Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["HRHG 2022\u2010 Keystone"],"award-info":[{"award-number":["HRHG 2022\u2010 Keystone"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Diffuse gliomas are primary brain tumors including glioblastomas (GB), astrocytomas, and oligodendrogliomas, the latter two harboring IDH1 mutations and exhibiting slower progression. Gliomas display cellular plasticity, with transitions between astrocyte\u2010like, oligodendrocyte\u2010like, progenitor\u2010like, and mesenchymal\u2010like states driven by genetic alterations and microenvironmental signals. The proneural\u2010to\u2010mesenchymal transition (PMT), associated with increased malignancy, is tightly regulated by the tumor microenvironment, notably through cytokine signaling and non\u2010tumor cell interactions. Endothelins (ET\u20101, ET\u20102, ET\u20103), vasoactive peptides mainly produced by vascular cells, signal through the G\u2010protein\u2010coupled receptors EDNRA and EDNRB and were previously suggested to promote glioma proliferation based on serum\u2010based models. Here, we revisited endothelin signaling using eleven serum\u2010free glioma lines and tumor samples. Multi\u2010omics and electrophysiological analyses identified EDNRB as the predominant receptor, enriched in astrocyte\u2010like cells, increased by BMPs or growth factor withdrawal, and repressed by interferons, IL\u20106 family cytokines, endothelins, and Hippo\/YAP signaling. EDNRA was confined to a perivascular tumor subpopulation and induced by Notch signaling selectively in GB. Functionally, endothelins reduced proliferation while promoting migration and PMT via EDNRB\u2010dependent Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling, ERK\/STAT3 activation, and apamin\u2010sensitive SK2\/SK3 potassium channel activity. Collectively these findings establish endothelin signaling as an important regulator of glioma cell plasticity and behavior.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70223","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T06:26:09Z","timestamp":1777011969000},"page":"1933-1962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["EDNRB\u2010dependent endothelin signaling reduces proliferation and promotes proneural\u2010to\u2010mesenchymal transition in gliomas"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7117-1595","authenticated-orcid":false,"given":"Donovan","family":"Pineau","sequence":"first","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle Universit\u00e9 de Montpellier, CNRS, INSERM  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