{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:03:26Z","timestamp":1789506206009,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000771","name":"Prostate Cancer UK","doi-asserted-by":"publisher","award":["RIA15\u2010ST2\u2010005"],"award-info":[{"award-number":["RIA15\u2010ST2\u2010005"]}],"id":[{"id":"10.13039\/501100000771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M008770\/1"],"award-info":[{"award-number":["BB\/M008770\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/T008369\/1"],"award-info":[{"award-number":["BB\/T008369\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>Treatment resistance has become a major challenge in cancer research, particularly for patients with advanced castration resistant prostate cancer (CRPC) where no curative therapies are available. Epigenetic alterations play a significant role in cancer progression. In prostate cancer (PCa), where androgen receptor (AR) is the primary oncogenic driver, epigenetic coregulators, specifically lysine demethylases (KDMs), have previously been identified as factors that alter the transcriptome as cancer cells acquire resistance. KDM7A has been identified as a cancer\u2010promoting factor in many cancers; however, its role in PCa remains largely unexplored. This study investigates the clinical relevance of KDM7A in comparison with the well\u2010studied KDM1A in PCa. Using PCa cell line models, we confirm KDM7A as an AR coregulator. By exploiting commercially available pharmacological inhibitors, we demonstrate that in AR\u2010positive CRPC cell lines, combinatory inhibition of KDM1A and KDM7A leads to a loss of AR and the AR\u2010driven transcriptome, which in turn attenuates cancer\u2010promoting cell phenotypes. These findings highlight the potential of combination\u2010targeted therapies in tackling advanced prostate cancers.<\/jats:p>","DOI":"10.1002\/1878-0261.70238","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:41:27Z","timestamp":1774284087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>KDM7A<\/scp>\n                    and\n                    <scp>KDM1A<\/scp>\n                    inhibition suppresses tumour promoting pathways in prostate cancer"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-224X","authenticated-orcid":false,"given":"Jennie N","family":"Jeyapalan","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham  Sutton Bonington UK"},{"name":"Biodiscovery Institute, University of Nottingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika M","family":"Metzler","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham  Sutton Bonington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"de Brot","sequence":"additional","affiliation":[{"name":"COMPATH, Institute of Animal Pathology, University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne L","family":"Woodcock","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham  Sutton Bonington UK"},{"name":"Biodiscovery Institute, University of Nottingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E","family":"Harris","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham  Sutton Bonington UK"},{"name":"Biodiscovery Institute, University of Nottingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lothion\u2010Roy","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham  Sutton Bonington UK"},{"name":"Biodiscovery Institute, University of Nottingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeli M","family":"Nilsson","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham  Sutton Bonington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atara","family":"Ntekim","sequence":"additional","affiliation":[{"name":"Department of Oncology University Hospital Ibadan  Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Toss","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny L","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Ume\u00e5 University  Sweden"},{"name":"Department of Biomedical Sciences Malm\u00f6 Universitet  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Khani","sequence":"additional","affiliation":[{"name":"Department of Urology Weill Cornell Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Urology Weill Cornell Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine J","family":"Gudas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Weill Cornell Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Rakha","sequence":"additional","affiliation":[{"name":"Biodiscovery Institute, University of Nottingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Heery","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catrin S","family":"Rutland","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham  Sutton Bonington UK"},{"name":"Biodiscovery Institute, University of Nottingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5438-1126","authenticated-orcid":false,"given":"Nigel P","family":"Mongan","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Sciences, University of Nottingham  Sutton Bonington UK"},{"name":"Biodiscovery Institute, University of Nottingham  UK"},{"name":"Department of Pharmacology Weill Cornell Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.18632\/oncotarget.12554","article-title":"Androgen receptor\u2010dependent and \u2010independent mechanisms driving prostate cancer progression: opportunities for therapeutic targeting from multiple angles","volume":"8","author":"Hoang DT","year":"2017","journal-title":"Oncotarget"},{"issue":"9","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/s44321-025-00282-8","article-title":"New frontiers in prostate cancer treatment from systemic therapy to targeted therapy","volume":"17","author":"Nouruzi S","year":"2025","journal-title":"EMBO Mol Med"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"365","article-title":"Mechanisms of resistance in castration\u2010resistant prostate cancer (CRPC)","volume":"4","author":"Chandrasekar T","year":"2015","journal-title":"Transl Androl Urol"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel RL","year":"2020","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/aps.2014.18","article-title":"Androgen receptor: structure, role in prostate cancer and drug discovery","volume":"36","author":"Tan MH","year":"2015","journal-title":"Acta Pharmacol Sin"},{"issue":"12","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202152764","article-title":"The androgen receptor depends on ligand\u2010binding domain dimerization for transcriptional activation","volume":"22","author":"El Kharraz S","year":"2021","journal-title":"EMBO Rep"},{"issue":"12","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1158\/1535-7163.MCT-22-0340","article-title":"Exploiting ligand\u2010binding domain dimerization for development of novel androgen receptor inhibitors","volume":"21","author":"Helsen C","year":"2022","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1210\/edrv.23.2.0460","article-title":"Androgen receptor (AR) coregulators: an overview","volume":"23","author":"Heinlein CA","year":"2002","journal-title":"Endocr Rev"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116338","article-title":"Androgen receptor cofactors: a potential role in understanding prostate cancer","volume":"173","author":"Li X","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"34","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"35710","DOI":"10.18632\/oncotarget.5958","article-title":"MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators","volume":"6","author":"Nilsson EM","year":"2015","journal-title":"Oncotarget"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jsbmb.2015.07.006","article-title":"Recent progress in the development of protein\u2010protein interaction inhibitors targeting androgen receptor\u2010coactivator binding in prostate cancer","volume":"161","author":"Biron E","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1006101","article-title":"Exploring anti\u2010androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer","volume":"13","author":"Harris AE","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1360430","article-title":"Molecular landscape for risk prediction and personalized therapeutics of castration\u2010resistant prostate cancer: at a glance","volume":"15","author":"Jian J","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7057","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature04020","article-title":"LSD1 demethylates repressive histone marks to promote androgen\u2010receptor\u2010dependent transcription","volume":"437","author":"Metzger E","year":"2005","journal-title":"Nature"},{"issue":"23","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1158\/0008-5472.CAN-06-1570","article-title":"Androgen receptor coactivators lysine\u2010specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence","volume":"66","author":"Kahl P","year":"2006","journal-title":"Cancer Res"},{"issue":"3","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.molonc.2013.01.003","article-title":"The lysine specific demethylase\u20101 (LSD1\/KDM1A) regulates VEGF\u2010a expression in prostate cancer","volume":"7","author":"Kashyap V","year":"2013","journal-title":"Mol Oncol"},{"issue":"18","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1073\/pnas.1804205115","article-title":"LSD1: a single target to combat lineage plasticity in lethal prostate cancer","volume":"115","author":"Ellis L","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"18","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"E4179","DOI":"10.1073\/pnas.1719168115","article-title":"LSD1 activates a lethal prostate cancer gene network independently of its demethylase function","volume":"115","author":"Sehrawat A","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3892\/ol.2020.12354","article-title":"Downregulation of lysine\u2010specific demethylase 1 enhances the sensitivity of hormone\u2010sensitive prostate cancer cells to androgen deprivation therapy","volume":"21","author":"Wang M","year":"2021","journal-title":"Oncol Lett"},{"issue":"10","key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/s41588-020-0681-7","article-title":"Chromatin binding of FOXA1 is promoted by LSD1\u2010mediated demethylation in prostate cancer","volume":"52","author":"Gao S","year":"2020","journal-title":"Nat Genet"},{"issue":"10","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1158\/0008-5472.CAN-22-2433","article-title":"LSD1 inhibition disrupts super\u2010enhancer\u2010driven oncogenic transcriptional programs in castration\u2010resistant prostate cancer","volume":"83","author":"Li M","year":"2023","journal-title":"Cancer Res"},{"issue":"6","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2005.08.027","article-title":"Regulation of LSD1 histone demethylase activity by its associated factors","volume":"19","author":"Shi YJ","year":"2005","journal-title":"Mol Cell"},{"issue":"2","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/cr.2010.5","article-title":"Dual\u2010specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4","volume":"20","author":"Huang C","year":"2010","journal-title":"Cell Res"},{"issue":"1","key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nsmb.1753","article-title":"Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases","volume":"17","author":"Horton JR","year":"2010","journal-title":"Nat Struct Mol Biol"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"18709","DOI":"10.1038\/srep18709","article-title":"G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation","volume":"5","author":"Pan MR","year":"2015","journal-title":"Sci Rep"},{"issue":"16","key":"e_1_2_11_27_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165658","article-title":"Histone demethylase KDM7A regulates androgen receptor activity, and its chemical inhibitor TC\u2010E 5002 overcomes cisplatin\u2010resistance in bladder cancer cells","volume":"21","author":"Lee KH","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"5","key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/ijc.32649","article-title":"Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation","volume":"146","author":"Mallm JP","year":"2020","journal-title":"Int J Cancer"},{"issue":"2","key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/jcp.29008","article-title":"Histone demethylase KDM7A is required for stem cell maintenance and apoptosis inhibition in breast cancer","volume":"235","author":"Meng Z","year":"2020","journal-title":"J Cell Physiol"},{"key":"e_1_2_11_30_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.664375","article-title":"The Jumonji domain\u2010containing histone demethylase homolog 1D\/lysine demethylase 7A (JHDM1D\/KDM7A) is an epigenetic activator of RHOJ transcription in breast cancer cells","volume":"9","author":"Zhang Z","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_11_31_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107945","article-title":"Structure\u2010based identification of a potent KDM7A inhibitor exerts anticancer activity through transcriptionally reducing MKRN1 in taxol\u2010 resistant and \u2010sensitive triple\u2010negative breast cancer cells","volume":"153","author":"Shi JJ","year":"2024","journal-title":"Bioorg Chem"},{"issue":"11","key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1002\/ijc.31843","article-title":"Histone demethylase KDM7A controls androgen receptor activity and tumor growth in prostate cancer","volume":"143","author":"Lee KH","year":"2018","journal-title":"Int J Cancer"},{"issue":"5","key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami E","year":"2012","journal-title":"Cancer Discov"},{"issue":"23","key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.1073\/pnas.1902651116","article-title":"Genomic correlates of clinical outcome in advanced prostate cancer","volume":"116","author":"Abida W","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nm.4045","article-title":"Divergent clonal evolution of castration\u2010resistant neuroendocrine prostate cancer","volume":"22","author":"Beltran H","year":"2016","journal-title":"Nat Med"},{"issue":"6","key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41371-018-0062-1","article-title":"Decreased expression of JHDMID in placenta is associated with preeclampsia through HLA\u2010G","volume":"32","author":"Luo S","year":"2018","journal-title":"J Hum Hypertens"},{"issue":"11","key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.humpath.2010.12.025","article-title":"Lysine\u2010specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors","volume":"42","author":"Schildhaus HU","year":"2011","journal-title":"Hum Pathol"},{"key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2051-5960-1-19","article-title":"The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma","volume":"1","author":"Pajtler KW","year":"2013","journal-title":"Acta Neuropathol Commun"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1116424","article-title":"The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer","volume":"11","author":"Metzler VM","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ccr.2012.11.010","article-title":"The androgen receptor induces a distinct transcriptional program in castration\u2010resistant prostate cancer in man","volume":"23","author":"Sharma NL","year":"2013","journal-title":"Cancer Cell"},{"issue":"5","key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ccr.2010.03.018","article-title":"An integrated network of androgen receptor, polycomb, and TMPRSS2\u2010ERG gene fusions in prostate cancer progression","volume":"17","author":"Yu J","year":"2010","journal-title":"Cancer Cell"},{"issue":"1","key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson JT","year":"2011","journal-title":"Nat Biotechnol"},{"issue":"7","key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao Y","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson MD","year":"2010","journal-title":"Bioinformatics"},{"issue":"1","key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"W130","DOI":"10.1093\/nar\/gkx356","article-title":"WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit","volume":"45","author":"Wang J","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"51","key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"E5593","DOI":"10.1073\/pnas.1419161111","article-title":"rMATS: robust and flexible detection of differential alternative splicing from replicate RNA\u2010Seq data","volume":"111","author":"Shen S","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"e_1_2_11_47_1","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1042\/BST0341089","article-title":"The androgen receptor DNA\u2010binding domain determines androgen selectivity of transcriptional response","volume":"34","author":"Verrijdt G","year":"2006","journal-title":"Biochem Soc Trans"},{"issue":"12","key":"e_1_2_11_48_1","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2016.74","article-title":"The HIF\/PHF8\/AR axis promotes prostate cancer progression","volume":"5","author":"Tong D","year":"2016","journal-title":"Oncogene"},{"issue":"46","key":"e_1_2_11_49_1","doi-asserted-by":"crossref","first-page":"75585","DOI":"10.18632\/oncotarget.12310","article-title":"c\u2010MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration\u2010resistant prostate cancer","volume":"7","author":"Maina PK","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"e_1_2_11_50_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/path.5557","article-title":"Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2","volume":"253","author":"Liu Q","year":"2021","journal-title":"J Pathol"},{"issue":"1","key":"e_1_2_11_51_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/path.6325","article-title":"Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1\u2010SNAI1 axis","volume":"264","author":"Wang Z","year":"2024","journal-title":"J Pathol"},{"issue":"18","key":"e_1_2_11_52_1","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.1021\/jm400624b","article-title":"Identification of the KDM2\/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity","volume":"56","author":"Suzuki T","year":"2013","journal-title":"J Med Chem"},{"issue":"11","key":"e_1_2_11_53_1","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1002\/ijc.27555","article-title":"Impairment of prostate cancer cell growth by a selective and reversible lysine\u2010specific demethylase 1 inhibitor","volume":"131","author":"Willmann D","year":"2012","journal-title":"Int J Cancer"},{"key":"e_1_2_11_54_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13148-016-0264-8","article-title":"Epigenetic modulators as therapeutic targets in prostate cancer","volume":"8","author":"Graca I","year":"2016","journal-title":"Clin Epigenetics"},{"issue":"6","key":"e_1_2_11_55_1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41388-021-02135-3","article-title":"RB1 loss in castration\u2010resistant prostate cancer confers vulnerability to LSD1 inhibition","volume":"41","author":"Han W","year":"2022","journal-title":"Oncogene"},{"key":"e_1_2_11_56_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.855167","article-title":"Cross\u2010talk between histone Methyltransferases and demethylases regulate REST transcription during neurogenesis","volume":"12","author":"Swaminathan J","year":"2022","journal-title":"Front Oncol"},{"issue":"5","key":"e_1_2_11_57_1","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/j.celrep.2014.11.008","article-title":"Lysine\u2010specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity","volume":"9","author":"Cai C","year":"2014","journal-title":"Cell Rep"},{"issue":"7158","key":"e_1_2_11_58_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature06092","article-title":"p53 is regulated by the lysine demethylase LSD1","volume":"449","author":"Huang J","year":"2007","journal-title":"Nature"},{"issue":"1","key":"e_1_2_11_59_1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3892\/or.2015.4362","article-title":"Overexpression of lysine\u2010specific demethylase 1 promotes androgen\u2010independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway","volume":"35","author":"Li X","year":"2016","journal-title":"Oncol Rep"},{"issue":"15","key":"e_1_2_11_60_1","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167440","article-title":"LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function","volume":"8","author":"Kumaraswamy A","year":"2023","journal-title":"JCI Insight"},{"issue":"7","key":"e_1_2_11_61_1","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1158\/0008-5472.CAN-11-3132","article-title":"Pten loss and RAS\/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem\/progenitor cells","volume":"72","author":"Mulholland DJ","year":"2012","journal-title":"Cancer Res"},{"key":"e_1_2_11_62_1","first-page":"457","article-title":"A review of the pathophysiological mechanisms underlying castration\u2010resistant prostate cancer","volume":"13","author":"Crowley F","year":"2021","journal-title":"Res Rep Urol"},{"key":"e_1_2_11_63_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ymeth.2024.11.008","article-title":"Inferring causal relationships among histone modifications in exon skipping event","volume":"232","author":"Feng P","year":"2024","journal-title":"Methods"},{"issue":"17","key":"e_1_2_11_64_1","doi-asserted-by":"crossref","first-page":"15586","DOI":"10.1021\/acs.jmedchem.4c01250","article-title":"Design, synthesis, and biological evaluation of potent EZH2\/LSD1 dual inhibitors for prostate cancer","volume":"67","author":"Le M","year":"2024","journal-title":"J Med Chem"},{"key":"e_1_2_11_65_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116801","article-title":"HSP90\/LSD1 dual inhibitors against\u00a0prostate cancer as well as patient\u2010derived colorectal organoids","volume":"278","author":"Tang DW","year":"2024","journal-title":"Eur J Med Chem"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.70238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1878-0261.70238","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.70238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:41:34Z","timestamp":1774284094000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.70238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":64,"alternative-id":["10.1002\/1878-0261.70238"],"URL":"https:\/\/doi.org\/10.1002\/1878-0261.70238","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v4\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/1878-0261.70238\/v3\/response1","asserted-by":"object"}]},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"2025-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1878-0261.70238"}}