{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:13:42Z","timestamp":1778253222713,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Stem\u2010like T\u00a0cells are central to the efficacy of programmed cell death protein 1 (PD1) blockade, sustaining long\u2010term immune responses by serving as a renewable reservoir for anti\u2010tumor effector CD8+ T\u00a0cells. However, the mechanisms governing their maintenance and regulation in cancer remain incompletely understood. Addressing this gap, Hor\n                    <jats:italic>et\u00a0al<\/jats:italic>\n                    . combined high\u2010dimensional 3D\u2010imaging with immunological profiling to define the niche of stem\u2010like T\u00a0cells within tumor\u2010draining lymph nodes in murine cancer models. Their study identifies a critical role for conventional type 1 dendritic cells (cDC1s) and the PD1 pathway in preserving high\u2010affinity tumor\u2010specific stem\u2010like T\u00a0cells. cDC1s deliver sustained T\u2010cell receptor (TCR) stimulation together with PD\u2010L1\/2 co\u2010inhibitory signals that support stemness, proliferation, and survival. Strikingly, disruption of PD1 signaling transiently enhances effector T\u00a0cell expansion but promotes differentiation and apoptosis of stem\u2010like T\u00a0cells, ultimately depleting this essential pool. These findings reveal a potential long\u2010term vulnerability of immune checkpoint blockade, particularly when tumors are not eradicated during the initial treatment response.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70257","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:14:30Z","timestamp":1776683670000},"page":"1093-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Checkpoint blockade and the stem\u2010like T\u00a0cell trade\u2010off"],"prefix":"10.1002","volume":"20","author":[{"given":"Julie M.","family":"Mazet","sequence":"first","affiliation":[{"name":"Department of Fundamental Oncology University of Lausanne  Switzerland"},{"name":"Ludwig Institute for Cancer Research University of Lausanne  Switzerland"},{"name":"Agora Cancer Research Centre  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6332-2598","authenticated-orcid":false,"given":"Johanna A.","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Fundamental Oncology University of Lausanne  Switzerland"},{"name":"Ludwig Institute for Cancer Research University of Lausanne  Switzerland"},{"name":"Agora Cancer Research Centre  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00574-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-025-01161-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.11.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19330"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.12.021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abg7836"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.08.026"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210749"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09440-x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3307"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00617"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35948-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.11.004"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.70257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1878-0261.70257","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.70257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:42:01Z","timestamp":1778251321000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.70257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/1878-0261.70257"],"URL":"https:\/\/doi.org\/10.1002\/1878-0261.70257","archive":["Portico"],"relation":{},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}