{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:13:12Z","timestamp":1780053192443,"version":"3.54.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008648","name":"Pfizer Foundation","doi-asserted-by":"publisher","award":["88778749"],"award-info":[{"award-number":["88778749"]}],"id":[{"id":"10.13039\/100008648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the growing field of precision oncology likely requires advanced CTC phenotyping. While their predictive value for disease progression and therapy response has extensively been shown, the low number of CTCs that are obtained from whole blood tubes limits their clinical application. The magnetic enrichment of CTCs using the FDA\u2010cleared CellSearch system is limited by the expression of the epithelial cell adhesion molecule (EpCAM) on CTC, and an increase in CTC yield may be obtained through enhanced capture of low EpCAM expressing cells. In this study, we compared the Flow Enabled Target Capture Halbach (FETCH) magnetic enrichment technology with the FDA\u2010cleared CellSearch system for CTC capture using paired blood samples from 34 patients with non\u2010small\u2010cell lung, breast, and prostate cancer. Results show a statistically significant median 1.5\u2010fold increase in CTCs captured with the FETCH system compared with CellSearch, accompanied by a median twofold reduction in non\u2010specifically captured leukocytes. This increase in CTC capture can aid the comprehensive analysis of CTCs in a larger number of patients, further supporting clinical implementation of CTC\u2010based diagnostics.<\/jats:p>","DOI":"10.1002\/1878-0261.70267","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:47:11Z","timestamp":1780051631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flow Enabled Target Capture Halbach\u2010based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8643-7235","authenticated-orcid":false,"given":"Michiel","family":"Stevens","sequence":"first","affiliation":[{"name":"Tzu Cancer Therapeutics  Amsterdam The Netherlands"},{"name":"Personalized Diagnosis and Therapeutics, Faculty of Science and Technology University of Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Mentink","sequence":"additional","affiliation":[{"name":"Personalized Diagnosis and Therapeutics, Faculty of Science and Technology University of Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Niessink","sequence":"additional","affiliation":[{"name":"Tzu Cancer Therapeutics  Amsterdam The Netherlands"},{"name":"Personalized Diagnosis and Therapeutics, Faculty of Science and Technology University of Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Coumans","sequence":"additional","affiliation":[{"name":"Decisive Science  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Mekenkamp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2470-5876","authenticated-orcid":false,"given":"Ruchi","family":"Bansal","sequence":"additional","affiliation":[{"name":"Personalized Diagnosis and Therapeutics, Faculty of Science and Technology University of Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Hiltermann","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University Hospital Groningen  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040867"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"6302","DOI":"10.1158\/1078-0432.CCR-08-0872","article-title":"Circulating tumor cells predict survival benefit from treatment in metastatic 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