{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:09:20Z","timestamp":1779804560328,"version":"3.53.1"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_166578"],"award-info":[{"award-number":["31003A_166578"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_173219"],"award-info":[{"award-number":["31003A_173219"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>The cyclin D binding Myb\u2010like Transcription Factor 1 (DMTF1) is a haploinsufficient tumor suppressor in various tumors. Alternative splicing generates a dominant negative, truncated version of full\u2010length DMTF1\u03b1, named DMTF1\u03b2. DMTF1\u03b2 has so far been described as an oncogene in breast cancer development. However, a clear understanding of how DMTF1\u03b2 contributes to carcinogenesis remains unknown. Analyzing DMTF1\u03b2 protein expression in breast cancer cell lines, as well as a highly metastatic prostate cancer cell line, confirmed a positive correlation between DMTF1\u03b2 expression and tumorigenic potential. Specifically, knocking down DMTF1\u03b2 in aggressive MDA\u2010MB\u2010231 breast and PC3MPRO4 prostate cancer cells significantly reduced wound closure and tissue invasion. \u03b2\u2010specific interactome and RNA\u2010sequencing studies in DMTF1\u03b2 overexpressing and knockdown cells, respectively, suggest that DMTF1\u03b2 expression is associated with the autophagy recycling pathway. Depleting DMTF1\u03b2 levels in cancer cells significantly decreased autophagic flux. Moreover, inhibiting autophagy led to decreased migration of DMTF1\u03b2 expressing breast cancer cells. Mechanistically, DMTF1\u03b2 protein interacts with and stabilizes the key autophagy protein ULK1. In conclusion, we identified a novel function for the alternatively spliced DMTF1 gene product in autophagy\u2010dependent cancer cell motility.<\/jats:p>","DOI":"10.1002\/1878-0261.70275","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:07:44Z","timestamp":1779800864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oncogenic\n                    <scp>DMTF1\u03b2<\/scp>\n                    promotes cancer cell motility by regulating autophagy through\n                    <scp>ULK1<\/scp>\n                    stabilization"],"prefix":"10.1002","author":[{"given":"Jun","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, Division of Experimental Pathology University of Bern  Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas J.","family":"Niklaus","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, Division of Experimental Pathology University of Bern  Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Schl\u00e4fli","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, Division of Experimental Pathology University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Tokarchuk","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, Division of Experimental Pathology University of Bern  Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Humbert","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, Division of Experimental Pathology University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"La Manna","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Division of Urology University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bich","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Biology University of Fribourg  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Maul","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, Division of Experimental Pathology University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Radpour","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Division of Tumor immunology University of Bern  Switzerland"},{"name":"Department of Medical Oncology, Inselspital, Bern University Hospital University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Kruithof\u2010de Julio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Division of Urology University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inti","family":"Zlobec","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, Division of Experimental Pathology University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9453-4614","authenticated-orcid":false,"given":"J\u00f6rn","family":"Dengjel","sequence":"additional","affiliation":[{"name":"Department of Biology University of Fribourg  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Torbett","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology The Scripps Research Institute  La Jolla CA USA"},{"name":"Department of Pediatrics, School of Medicine University of Washington  Seattle WA USA"},{"name":"Center for Immunity and Immunotherapies Seattle Children's Research Institute  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5897-3647","authenticated-orcid":false,"given":"Mario P.","family":"Tschan","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, Division of Experimental Pathology University of Bern  Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1073\/pnas.96.7.3993","article-title":"Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1","volume":"96","author":"Inoue K","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"29188","DOI":"10.1074\/jbc.273.44.29188","article-title":"Regulation of the CD13\/aminopeptidase N gene by DMP1, a transcription factor antagonized by D\u2010type cyclins","volume":"273","author":"Inoue K","year":"1998","journal-title":"J Biol Chem"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/ijc.24938","article-title":"The Arf\u2010inducing transcription factor Dmp1 encodes a transcriptional activator of Amphiregulin, Thrombospondin\u20101, JunB and Egr1","volume":"126","author":"Mallakin A","year":"2010","journal-title":"Int J Cancer"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bbagrm.2015.07.009","article-title":"Human DMTF1\u03b2 antagonizes DMTF1\u03b1 regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation","volume":"1849","author":"Tschan MP","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/07357907.2017.1303505","article-title":"Stabilization of the p53\u2010DNA complex by the nuclear protein Dmp1\u03b1","volume":"35","author":"Kendig RD","year":"2017","journal-title":"Cancer Invest"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1158\/0008-5472.CAN-11-2410","article-title":"Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function","volume":"72","author":"Frazier DP","year":"2012","journal-title":"Cancer Res"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1038\/sj.onc.1208615","article-title":"The p53 pathway: positive and negative feedback loops","volume":"24","author":"Harris SL","year":"2005","journal-title":"Oncogene"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1097-2765(01)00214-3","article-title":"PUMA, a novel proapoptotic gene, is induced by p53","volume":"7","author":"Nakano K","year":"2001","journal-title":"Mol Cell"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"42750","DOI":"10.1074\/jbc.M307067200","article-title":"Alternative splicing of the human cyclin D\u2010binding Myb\u2010like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns","volume":"278","author":"Tschan MP","year":"2003","journal-title":"J Biol Chem"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/path.4504","article-title":"DMP1\u03b2, a splice isoform of the tumour\u00a0suppressor DMP1 locus, induces proliferation and progression of breast cancer","volume":"236","author":"Maglic D","year":"2015","journal-title":"J Pathol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1016\/j.bbrc.2018.08.042","article-title":"Cisplatin sensitivity in breast cancer cells is associated with particular DMTF1 splice variant expression","volume":"503","author":"Niklaus NJ","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ijc.30003","article-title":"Aberrant splicing of the DMP1\u2010ARF\u2010MDM2\u2010p53 pathway in cancer","volume":"139","author":"Inoue K","year":"2016","journal-title":"Int J Cancer"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"9084","DOI":"10.1158\/0008-5472.CAN-10-0159","article-title":"Critical roles of DMP1 in human epidermal growth factor receptor 2\/neu\u2010Arf\u2010p53 signaling and breast cancer development","volume":"70","author":"Taneja P","year":"2010","journal-title":"Cancer Res"},{"key":"e_1_2_11_15_1","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel RL","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"e_1_2_11_16_1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung H","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1101\/gad.315739.118","article-title":"Genetics and biology of prostate cancer","volume":"32","author":"Wang G","year":"2018","journal-title":"Genes Dev"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0140-6736(16)31891-8","article-title":"Breast cancer","volume":"389","author":"Harbeck N","year":"2017","journal-title":"The Lancet"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He C","year":"2009","journal-title":"Annu Rev Genet"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima N","year":"2011","journal-title":"Cell"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic I","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","article-title":"Autophagy pathway: cellular and molecular mechanisms","volume":"14","author":"Yu L","year":"2018","journal-title":"Autophagy"},{"key":"e_1_2_11_23_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17081375","article-title":"Development of a patient\u2010derived xenograft (PDX) of breast cancer bone metastasis in a zebrafish model","volume":"17","author":"Mercatali L","year":"2016","journal-title":"Int J Mol Sci"},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.aca.2019.08.032","article-title":"Filter aided sample preparation \u2013 a tutorial","volume":"1090","author":"Wi\u015bniewski JR","year":"2019","journal-title":"Anal Chim Acta"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2021.100066","article-title":"Scaffold\u2010free 3D cell culture of primary skin fibroblasts induces profound changes of the matrisome","volume":"11","author":"Vu B","year":"2021","journal-title":"Matrix Biol Plus"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.\u2010range mass accuracies and proteome\u2010wide protein quantification","volume":"26","author":"Cox J","year":"2008","journal-title":"Nat Biotechnol"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mpdhp.2011.12.003","article-title":"Molecular classification of breast carcinoma","volume":"18","author":"Alizart M","year":"2012","journal-title":"Diagn Histopathol"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/S0140-6736(11)61539-0","article-title":"Gene expression profiling in breast cancer: classification, prognostication, and prediction","volume":"378","author":"Reis\u2010Filho JS","year":"2011","journal-title":"The Lancet"},{"key":"e_1_2_11_29_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2019.102855","article-title":"Triple negative breast cancer: a thorough review of biomarkers","volume":"145","author":"Silva JL","year":"2020","journal-title":"Crit Rev Oncol Hematol"},{"key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","author":"Al\u2010Hajj M","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan D","year":"2011","journal-title":"Cell"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells11040649","article-title":"Epithelial mesenchymal transition (EMT) and associated invasive adhesions in solid and Haematological Tumours","volume":"11","author":"Greaves D","year":"2022","journal-title":"Cells"},{"key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.15252\/embj.201490784","article-title":"Autophagy in malignant transformation and cancer progression","volume":"34","author":"Galluzzi L","year":"2015","journal-title":"EMBO J"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1242\/jcs.188490","article-title":"Autophagy in\u00a0adhesion and migration","volume":"129","author":"Kenific CM","year":"2016","journal-title":"J Cell Sci"},{"key":"e_1_2_11_35_1","doi-asserted-by":"crossref","DOI":"10.3390\/biology8040071","article-title":"Autophagy and its relationship to epithelial to mesenchymal transition: when autophagy inhibition for cancer therapy turns counterproductive","volume":"8","author":"Rojas\u2010Sanchez G","year":"2019","journal-title":"Biology"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1096\/fj.201600698R","article-title":"LC3\/GABARAP family proteins: autophagy\u2010(un)related functions","volume":"30","author":"Schaaf MBE","year":"2016","journal-title":"FASEB J"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.15252\/embj.201696315","article-title":"Development of LC3\/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy","volume":"36","author":"Lee Y","year":"2017","journal-title":"EMBO J"},{"key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/pros.2990230206","article-title":"p53 oncogene mutations in three human prostate cancer cell lines","volume":"23","author":"Carroll AG","year":"1993","journal-title":"Prostate"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1038\/sj.onc.1209735","article-title":"Mutant p53 in MDA\u2010MB\u2010231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D","volume":"25","author":"Hui L","year":"2006","journal-title":"Oncogene"},{"key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.4161\/cc.22147","article-title":"Autophagy and tumor cell invasion","volume":"11","author":"Amaravadi RK","year":"2012","journal-title":"Cell Cycle"},{"key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.lungcan.2013.05.009","article-title":"Overexpression of beclin1 induced autophagy and apoptosis in lungs of K\u2010rasLA1 mice","volume":"81","author":"Shin JY","year":"2013","journal-title":"Lung Cancer"},{"key":"e_1_2_11_42_1","first-page":"1927","article-title":"Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy\u2010dependent pathway in human synovial sarcoma cells","volume":"40","author":"Zhu J","year":"2018","journal-title":"Oncol Rep"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.247056","article-title":"The pleiotropic functions of autophagy in metastasis","volume":"134","author":"Marsh T","year":"2021","journal-title":"J Cell Sci"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/onc.2016.333","article-title":"Autophagy in cancer metastasis","volume":"36","author":"Mowers EE","year":"2017","journal-title":"Oncogene"},{"key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1083\/jcb.201503075","article-title":"NBR1 enables autophagy\u2010dependent focal adhesion turnover","volume":"212","author":"Kenific CM","year":"2016","journal-title":"J Cell Biol"},{"key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.celrep.2016.04.065","article-title":"Autophagy promotes focal adhesion disassembly and cell motility of metastatic tumor cells through the direct interaction of Paxillin with LC3","volume":"15","author":"Sharifi MN","year":"2016","journal-title":"Cell Rep"},{"key":"e_1_2_11_47_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0006-291X(03)01165-3","article-title":"Cell shape provides global control of focal adhesion assembly","volume":"307","author":"Chen CS","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"e_1_2_11_48_1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/carcin\/bgt063","article-title":"Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial\u2010mesenchymal transition","volume":"34","author":"Li J","year":"2013","journal-title":"Carcinogenesis"},{"key":"e_1_2_11_49_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.bbamcr.2018.02.007","article-title":"Autophagy modulates transforming growth factor beta 1 induced\u00a0epithelial to mesenchymal transition in non\u2010small cell lung cancer cells","volume":"1865","author":"Alizadeh J","year":"2018","journal-title":"Biochimica et Biophysica Acta (BBA) \u2013 Molecular Cell Research"},{"key":"e_1_2_11_50_1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/1873-3468.12172","article-title":"Uncoordinated 51\u2010like kinase 2 signaling pathway\u00a0regulates epithelial\u2010mesenchymal transition in\u00a0A549 lung cancer cells","volume":"590","author":"Kim YH","year":"2016","journal-title":"FEBS Lett"},{"key":"e_1_2_11_51_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3389\/fcell.2020.00545","article-title":"The autophagy machinery contributes to E\u2010cadherin turnover in breast cancer","volume":"8","author":"Damiano V","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_11_52_1","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1158\/1541-7786.MCR-19-0321","article-title":"Sirtuin6 (SIRT6) promotes the EMT of hepatocellular carcinoma by stimulating Autophagic degradation of E\u2010cadherin","volume":"17","author":"Han LL","year":"2019","journal-title":"Mol Cancer Res"},{"key":"e_1_2_11_53_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/ijo.2020.5146","article-title":"Mechanisms regulating DMTF1\u03b2\/\u03b3 expression and their functional interplay with DMTF1\u03b1","volume":"58","author":"Li J","year":"2021","journal-title":"Int J Oncol"},{"key":"e_1_2_11_54_1","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1128\/MCB.18.3.1590","article-title":"Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D\u2010type cyclins through a cyclin\u2010dependent\u2010kinase\u2010independent mechanism","volume":"18","author":"Inoue K","year":"1998","journal-title":"Mol Cell Biol"},{"key":"e_1_2_11_55_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/biom8020014","article-title":"p53\u2010mediated molecular control of autophagy in tumor cells","volume":"8","author":"Mrakovcic M","year":"2018","journal-title":"Biomolecules"},{"key":"e_1_2_11_56_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ceb.2009.12.001","article-title":"Autophagy regulation by p53","volume":"22","author":"Maiuri MC","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"e_1_2_11_57_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4161\/auto.1.3.2051","article-title":"p53, autophagy and tumor suppression","volume":"1","author":"Jin S","year":"2005","journal-title":"Autophagy"},{"key":"e_1_2_11_58_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.abb.2007.03.034","article-title":"Selective degradation of mitochondria by mitophagy","volume":"462","author":"Kim I","year":"2007","journal-title":"Arch Biochem Biophys"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.70275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1878-0261.70275","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.70275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:07:51Z","timestamp":1779800871000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.70275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":57,"alternative-id":["10.1002\/1878-0261.70275"],"URL":"https:\/\/doi.org\/10.1002\/1878-0261.70275","archive":["Portico"],"relation":{},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2025-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1878-0261.70275"}}