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We tested whether the tumor microenvironment, particularly B\u2010cell infiltration, could predict overall survival after platinum chemotherapy. Pretreatment tumors from 189 patients in three cohorts treated with cisplatin\u2010 or carboplatin\u2010based regimens underwent bulk transcriptome profiling. Immune cell infiltration and multicellular communities were inferred from gene expression and associated with overall survival using cohort\u2010specific multivariable models and meta\u2010analysis. Higher lymphocyte infiltration was associated with longer overall survival (hazard ratio 0.34, 95% confidence interval 0.16\u20130.72), driven by B cells and memory B cells (hazard ratio 0.19, 95% confidence interval 0.05\u20130.75). These associations were confined to cisplatin\u2010treated patients and were strongest in tumors with a pro\u2010inflammatory B\u2010cell\u2010rich community and concordant B\u2010cell gene expression signatures. In contrast, higher myeloid infiltration was associated with shorter overall survival. Pretreatment B\u2010cell enrichment in the tumor microenvironment identified a subset associated with improved overall survival among patients receiving platinum chemotherapy, particularly cisplatin, supporting B\u2010cell\u2010focused biomarker development and spatial characterization of tertiary lymphoid structures in urothelial cancer.<\/jats:p>","DOI":"10.1002\/1878-0261.70276","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:41:14Z","timestamp":1780375274000},"page":"2340-2355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor B\u2010cell infiltration in platinum\u2010treated advanced muscle\u2010invasive urothelial carcinoma"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6550-3384","authenticated-orcid":false,"given":"Konrad","family":"Stawiski","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Dana Farber Cancer Institute  Boston MA USA"},{"name":"Department of Biostatistics and Translational Medicine Medical University of Lodz  Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Perera\u2010Bel","sequence":"additional","affiliation":[{"name":"PSMAR Hospital del Mar Medical Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejo","family":"Rodriguez\u2010Vida","sequence":"additional","affiliation":[{"name":"PSMAR Hospital del Mar Medical Research Institute (IMIM)  Barcelona Spain"},{"name":"Medical Oncology Department Hospital del Mar, CIBERONC  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Juanpere","sequence":"additional","affiliation":[{"name":"PSMAR Hospital del Mar Medical Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Michaud","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, Department of Surgery Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Guerriero","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, Department of Surgery Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent W.","family":"Mouw","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Dana Farber Cancer Institute  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"},{"name":"Department of Radiation Oncology Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotelis","family":"Bamias","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-6512","authenticated-orcid":false,"given":"Filipe L. 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