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PTCs may become highly aggressive anaplastic thyroid cancers (ATCs). While single\u2010cell transcriptomics may resolve this heterogeneity, it is potentially confounded by technical effects whose correction may dampen inter\u2010tumor variations. Here we profiled ATCs and\n                    <jats:italic>BRAF<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>V600E<\/jats:italic>\n                    <\/jats:sup>\n                    PTCs with single\u2010nuclei RNA\u2010seq and spatial transcriptomics, and an experimental design disentangling biological and technical variations. It reveals that much transcriptional variation in cancer cells and several immune cell types is idiosyncratic, that is, tumor\u2010specific, a phenomenon obscured by batch integration in a number of single\u2010cell studies. Idiosyncrasies are associated in some cases with genomic aberrations and global tissue states like hypoxia. Beyond idiosyncrasies, differentiation markers\n                    <jats:italic>SLC5A5<\/jats:italic>\n                    (\n                    <jats:italic>NIS<\/jats:italic>\n                    ),\n                    <jats:italic>TPO<\/jats:italic>\n                    ,\n                    <jats:italic>TG,<\/jats:italic>\n                    and\n                    <jats:italic>TSHR<\/jats:italic>\n                    are lost in a sequence mirrored by their gain during human thyroid organoids maturation, suggesting a new classification of cancer cell states. PTC cells retain\n                    <jats:italic>TSHR<\/jats:italic>\n                    expression and show features of partial epithelial\u2013mesenchymal transition (EMT) with a massive expression of\n                    <jats:italic>FN1<\/jats:italic>\n                    , which promotes proliferation via an autocrine loop. In contrast, ATCs undergo full\u2010scale EMT, with expression of mesenchymal extracellular components and loss of\n                    <jats:italic>TSHR<\/jats:italic>\n                    . Finally, we show that the microenvironment of cancer cells is driven by inflammation. These findings may help future stratifications of\n                    <jats:italic>BRAF<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>V600E<\/jats:italic>\n                    <\/jats:sup>\n                    PTCs.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70289","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:19:00Z","timestamp":1786443540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatial and single\u2010nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers"],"prefix":"10.1002","author":[{"given":"Adrien","family":"Tourneur","sequence":"first","affiliation":[{"name":"IRIBHM Jacques E. Dumont Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Rodrigues","family":"Vit\u00f3ria","sequence":"additional","affiliation":[{"name":"IRIBHM Jacques E. Dumont Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Saiselet","sequence":"additional","affiliation":[{"name":"IRIBHM Jacques E. 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