{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:09:41Z","timestamp":1790150981507,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>\n                    Endometriosis is a benign yet debilitating condition, and its molecular complexity remains unexplored. Although clinically recognized, its genetic landscape has long been overlooked. This review analyses cancer\u2010associated mutations (CAMs) identified in endometriotic lesions, revealing parallels with malignancy. Recurrent mutations in key oncogenic and tumour suppressor genes\u2014\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    ,\n                    <jats:italic>CTNNB1<\/jats:italic>\n                    ,\n                    <jats:italic>KRAS<\/jats:italic>\n                    ,\n                    <jats:italic>PTEN<\/jats:italic>\n                    and\n                    <jats:italic>ARID1A<\/jats:italic>\n                    \u2014emerge with patterns distinct from cancer, yet suggesting shared mechanisms. Despite the limited genomic data, these findings position endometriosis as a valuable model for investigating early tumour\u2010like processes. By reframing endometriosis through the lens of molecular oncology, this study offers new insights into its pathogenesis and proposes a translational framework for advancing diagnostics and understanding disease progression at the benign\u2013malignant interface.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70295","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:47:46Z","timestamp":1790149666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer\u2010associated mutations in endometriosis reframe a benign disease through molecular oncology"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1748-6337","authenticated-orcid":false,"given":"Clarissa","family":"Mujacic","sequence":"first","affiliation":[{"name":"Department of Precision Medicine in Surgical, Oncological, and Critical Care (Me.Pre.C.C.), Section of Medical Oncology University of Palermo  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concetta","family":"Vitale","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Surgical, Oncological, and Critical Care (Me.Pre.C.C.), Section of Medical Oncology University of Palermo  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Siino","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Surgical, Oncological, and Critical Care (Me.Pre.C.C.), Section of Medical Oncology University of Palermo  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Di Giovanni","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Surgical, Oncological, and Critical Care (Me.Pre.C.C.), Section of Medical Oncology University of Palermo  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ferrante Bannera","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Surgical, Oncological, and Critical Care (Me.Pre.C.C.), Section of Medical Oncology University of Palermo  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Di Marco","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Surgical, Oncological, and Critical Care (Me.Pre.C.C.), Section of Medical Oncology University of Palermo  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gottardo","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Surgical, Oncological, and Critical Care (Me.Pre.C.C.), Section of Medical Oncology University of Palermo  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tancredi Didier Bazan","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Surgical, Oncological, 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