{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:23:20Z","timestamp":1783689800201,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>\n                    Carcinoembryonic antigen\u2010related cell adhesion molecule 1 (CEACAM1) is widely expressed in human cells and undergoes marked alterations during tumorigenesis. However, its functional significance in invasive breast cancer (BC) remains insufficiently understood. In this study, CEACAM1 expression patterns in invasive BC tissues were analyzed and correlated with the proliferative index (PI) of the tumor cells. To assess isoform\u2010specific functional effects and identify CEACAM1\u2010responsive genes involved in key proliferation\u2010associated pathways, MCF\u20107 cells were transfected with either\n                    <jats:italic>CEACAM1<\/jats:italic>\n                    short cytoplasmic domain isoform (CEACAM1\u20104S) or\n                    <jats:italic>CEACAM1<\/jats:italic>\n                    long cytoplasmic domain isoform (CEACAM1\u20104L). BC tissues exhibited substantial heterogeneity in CEACAM1 expression, which correlated with the PI of the tumor cells. Functional\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies demonstrated that the CEACAM1\u20104L isoform exclusively suppresses cell proliferation. Transcriptome and protein\u2010level analyses revealed that CEACAM1\u20104L regulates the expression of key mediators involved in cell cycle control, apoptosis, extracellular matrix organization, and growth factor\u2010dependent signaling pathways. These findings highlight the biological significance of CEACAM1\u20104L isoform in BC, its potential diagnostic relevance for patient stratification, as well as its possible consideration in future therapeutic approaches.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70306","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:51:34Z","timestamp":1783687894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CEACAM1<\/scp>\n                    participation in breast cancer progression"],"prefix":"10.1002","author":[{"given":"Mykola","family":"Lyndin","sequence":"first","affiliation":[{"name":"Department of Anatomy University Hospital Essen  Essen Germany"},{"name":"Department of Pathology, Academic and Research Medical Institute Sumy State University  Sumy Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kube\u2010Golovin","sequence":"additional","affiliation":[{"name":"Department of Anatomy University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatolii","family":"Romaniuk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Academic and Research Medical Institute Sumy State University  Sumy Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3313-2475","authenticated-orcid":false,"given":"Gunther","family":"Wennemuth","sequence":"additional","affiliation":[{"name":"Department of Anatomy University Hospital Essen  Essen 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