{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:03:38Z","timestamp":1784275418867,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM130454"],"award-info":[{"award-number":["P20GM130454"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA023108"],"award-info":[{"award-number":["P30CA023108"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA200994"],"award-info":[{"award-number":["R01CA200994"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA262232"],"award-info":[{"award-number":["R01CA262232"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD030242"],"award-info":[{"award-number":["S10OD030242"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>\n                    Estrogen therapy elicits clinical benefit in ~\u200930% of patients with endocrine\u2010resistant estrogen receptor (ER)\u2010positive breast cancer, but its mechanism of action and strategies to increase efficacy remain unclear. Estrogen therapy can induce ER transcriptional hyperactivation and DNA damage; we postulated that such damage could be exacerbated by epigenetic dysregulation via inhibition of histone deacetylases (HDACi). We evaluated the effects of 17b\u2010estradiol and HDACi in three types of ER\n                    <jats:sup>+<\/jats:sup>\n                    breast cancer models: Cells adapted to growth following long\u2010term estrogen deprivation; cells engineered to overexpress exogenous ER that confers endocrine resistance; mice bearing endocrine\u2010resistant patient\u2010derived xenografts. Assay endpoints included apoptosis, growth, DNA damage, histone post\u2010translational modification, levels of ER\u2010regulated transcripts and encoded proteins, cell cycle and replication status, and genome\u2010wide chromatin accessibility, ER binding, and transcriptional profiles. Entinostat treatment increased histone acetylation and chromatin accessibility. Combination treatment with E2 and entinostat inhibited cell growth and induced apoptosis in ER\u2010overexpressing models. E2 and entinostat induced DNA damage as single agents and in combination. These agents synergized against tumor models, offering HDACi as a strategy to enhance efficacy of estrogen therapy.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70307","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:07:04Z","timestamp":1784272024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological chromatin remodeling enhances response to estrogen therapy in\n                    <scp>ER<\/scp>\n                    <sup>+<\/sup>\n                    breast cancer"],"prefix":"10.1002","author":[{"given":"Anneka L.","family":"Johnson Thomas","sequence":"first","affiliation":[{"name":"Department of Molecular and Systems Biology Dartmouth Geisel School of Medicine  Lebanon NH USA"},{"name":"Department of Pharmacology and Toxicology Medical College of Wisconsin  Milwaukee WI 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Dynamics The Rockefeller University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology Dartmouth Geisel School of Medicine  Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology Dartmouth Geisel School of Medicine  Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Birmingham","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malone K.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail E.","family":"Goen","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology Dartmouth Geisel School of Medicine  Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology Dartmouth Geisel School of Medicine  Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen M.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Geisel School of Medicine at Dartmouth  Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred W.","family":"Kolling","sequence":"additional","affiliation":[{"name":"Dartmouth Cancer Center Dartmouth Geisel School of Medicine  Hanover NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Demidenko","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Dartmouth Geisel School of Medicine  Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Jorns","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brock C.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology Dartmouth Geisel School of Medicine  Lebanon NH USA"},{"name":"Department of Epidemiology, Geisel School of Medicine Dartmouth College  Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-2909","authenticated-orcid":false,"given":"Todd 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