{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:44:00Z","timestamp":1786167840837,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009326","name":"Cancer Research Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>\n                    The mutational landscape of head &amp; neck and cutaneous squamous cell carcinomas (HNSCC, cSCC) has major gene alterations involving\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    ,\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    , and\n                    <jats:italic>TP53<\/jats:italic>\n                    among others that contribute to tumorigenesis. In this study, we focused on somatostatin receptor 4 (\n                    <jats:italic>SSTR4<\/jats:italic>\n                    ), which was identified in a recent\n                    <jats:italic>in vivo<\/jats:italic>\n                    HNSCC CRISPR screen. Mutations in the SSTR protein family are more commonly implicated in neuroendocrine tumors, and to date, no studies have shown a link between SSTR4 and cSCC\/HNSCC. To understand the role of Sstr4 in skin keratinocytes, we employed transcriptomic profiling and proteomic methods and identified enriched pathways and protein\u2013protein interactions (PPIs) networks. Sstr4 activation by J\u20102156 agonist regulated MAPK\u2010ERK signaling pathway, which simultaneously limited G1 to S phase cell cycle progression. To validate Sstr4 as a driver of cSCC\/HNSCC tumorigenesis, we performed a localized and clonal Sstr4 knockout in basal keratinocytes of the Pik3ca\n                    <jats:sup>H1047R<\/jats:sup>\n                    oncogenic mouse model using ultrasound\u2010guided\n                    <jats:italic>in\u2010utero<\/jats:italic>\n                    lentivirus injection technology. Tumor formation in mice following Sstr4 knockout occurred rapidly around 12\u2009weeks. Our study is the first to uncover Sstr4 role in cSCC\/HNSCC through\n                    <jats:italic>in\u2010vivo<\/jats:italic>\n                    models.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70316","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:19:09Z","timestamp":1786166349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Somatostatin receptor 4 (\n                    <scp>SSTR4<\/scp>\n                    ) is a tumor suppressor in cutaneous and head &amp; neck squamous cell carcinomas"],"prefix":"10.1002","author":[{"given":"Ali","family":"Taqvi","sequence":"first","affiliation":[{"name":"Division of Clinical and Translational Research, Faculty of Medicine and Health Sciences McGill University  Montreal Canada"},{"name":"Cancer Research Program Research Institute of the McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan Khang","family":"Huynh","sequence":"additional","affiliation":[{"name":"Division of Clinical and Translational Research, Faculty of Medicine and Health Sciences McGill University  Montreal Canada"},{"name":"Cancer Research Program Research Institute of the McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adway","family":"Kadam","sequence":"additional","affiliation":[{"name":"Cancer Research Program Research Institute of the McGill University Health Centre  Montreal Canada"},{"name":"Department of Surgical and Interventional Sciences, Faculty of Medicine and Health Sciences McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Kardan","sequence":"additional","affiliation":[{"name":"Cancer Research Program Research Institute of the McGill University Health Centre  Montreal Canada"},{"name":"Department of Surgical and Interventional Sciences, Faculty of Medicine and Health Sciences McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Clinical and Translational Research, Faculty of Medicine and Health Sciences McGill University  Montreal Canada"},{"name":"Cancer Research Program Research Institute of the McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina Jamal","family":"Laham","sequence":"additional","affiliation":[{"name":"Cancer Research Program Research Institute of the McGill University Health Centre  Montreal Canada"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine and Health Sciences McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-1466","authenticated-orcid":false,"given":"Sampath Kumar","family":"Loganathan","sequence":"additional","affiliation":[{"name":"Division of Clinical and Translational Research, Faculty of Medicine and Health Sciences McGill University  Montreal Canada"},{"name":"Cancer Research Program Research Institute of the McGill University Health Centre  Montreal Canada"},{"name":"Department of Surgical and Interventional Sciences, Faculty of Medicine and Health Sciences McGill University  Montreal Canada"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine and Health Sciences McGill University  Montreal Canada"},{"name":"Department of Biochemistry, and Rosalind and Morris Goodman Cancer Research Institute, Faculty of Medicine and Health Sciences McGill University  Montreal 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