{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:12:53Z","timestamp":1788351173220,"version":"build-2803163510"},"reference-count":95,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R16 GM145561"],"award-info":[{"award-number":["R16 GM145561"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>Various environmental and endogenous stressors, including ultraviolet (UV) radiation, cytotoxins, and dysregulated translation, can induce ribosome stalling and collisions, disrupting protein homeostasis. The ribotoxic stress response (RSR) is a cellular surveillance mechanism that senses translational stress and activates stress signaling via the MAP3 kinase ZAK\u03b1 and the stress\u2010activated protein kinases (SAPKs) p38 and JNK. This review outlines the molecular mechanisms behind RSR, distinguishes RSR from other translational stress response pathways, such as the well\u2010studied integrated stress response (ISR), discusses the role of RSR in key cellular processes, and presents new evidence linking RSR to cancer biology. We explore how ribotoxic stress is exploited by chemotherapeutic agents and other compounds to induce cancer cell death, and the potential limitations of such therapeutic strategy. Finally, we highlight future considerations for inducing the RSR pathway in cancer, highlighting both therapeutic potential and the challenges in this emerging field.<\/jats:p>","DOI":"10.1002\/1878-0261.70323","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:15:56Z","timestamp":1788347756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5156-9051","authenticated-orcid":false,"given":"Anastassiya","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Herbert H. Lehman College City University of New York  Bronx NY USA"},{"name":"Ph.D. Program in Biology, The Graduate Center City University of New York  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Aslam","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Herbert H. Lehman College City University of New York  Bronx NY USA"},{"name":"Ph.D. Program in Biology, The Graduate Center City University of New York  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elouise","family":"Torruella","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Herbert H. Lehman College City University of New York  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alphons","family":"Sony","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Herbert H. Lehman College City University of New York  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bronx Community College City University of New York  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simira","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Herbert H. Lehman College City University of New York  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Columba","family":"de la Parra","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Biology, The Graduate Center City University of New York  NY USA"},{"name":"Department of Chemistry, Herbert H. Lehman College City University of New York  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira","family":"Sauane","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Herbert H. Lehman College City University of New York  Bronx NY USA"},{"name":"Ph.D. Program in Biology, The Graduate Center City University of New York  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41392-024-01856-7","article-title":"Exploring treatment options in cancer: tumor treatment strategies","volume":"9","author":"Liu B","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"7347","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanh\u00fcusser B","year":"2011","journal-title":"Nature"},{"issue":"1","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks 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