{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:08:55Z","timestamp":1788768535702,"version":"build-2803163510"},"reference-count":109,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018706","name":"HORIZON EUROPE Widening participation and spreading excellence","doi-asserted-by":"publisher","award":["101079217"],"award-info":[{"award-number":["101079217"]}],"id":[{"id":"10.13039\/100018706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>\n                    Neoadjuvant chemoradiotherapy followed by total mesorectal excision is standard for locally advanced rectal cancer, but response varies and current markers are insufficient. This study integrates public bulk RNA\u2010seq data to identify predictive features of response.\n                    <jats:italic>TRIM54<\/jats:italic>\n                    and\n                    <jats:italic>PABPC4<\/jats:italic>\n                    were upregulated in the responder group, while\n                    <jats:italic>ADSS1<\/jats:italic>\n                    and\n                    <jats:italic>MGAT1<\/jats:italic>\n                    were upregulated in the non\u2010responder group.\n                    <jats:italic>ARMC2<\/jats:italic>\n                    was identified as a predictive biomarker upregulated in pathological complete response. Responder group showed enrichment of NK cells and CD4+ lymphocytes, while immune precursors were linked to poor outcome. Transcription factor analysis revealed\n                    <jats:italic>SP1<\/jats:italic>\n                    and\n                    <jats:italic>NFKB<\/jats:italic>\n                    activations in the non\u2010responder group and\n                    <jats:italic>TCF15<\/jats:italic>\n                    in the responder group.\n                    <jats:italic>SMAD3<\/jats:italic>\n                    and\n                    <jats:italic>RDXANK<\/jats:italic>\n                    were associated with complete regression, while\n                    <jats:italic>MYC<\/jats:italic>\n                    was dominant in incomplete regression. These findings provide insight into mechanisms underlying therapy response. To our knowledge, this is the first meta\u2010analysis using high\u2010throughput sequencing data, providing a valuable starting point for future rectal cancer research.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70324","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:28:56Z","timestamp":1788766136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Profiling neoadjuvant therapy response in rectal cancer using meta\u2010analysis of publicly available transcriptomic\n                    <scp>RNA<\/scp>\n                    \u2010seq datasets"],"prefix":"10.1002","author":[{"given":"Aleksandra","family":"Stanojevic","sequence":"first","affiliation":[{"name":"Department of Experimental Oncology Institute for Oncology and Radiology of Serbia (IORS)  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Stroggilos","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biomedical Research Foundation Academy of Athens (BRFAA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mladen","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Clinic for Radiation Oncology Institute for Oncology and Radiology of Serbia (IORS)  Belgrade Serbia"},{"name":"Faculty of Medicine University of Belgrade  Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Djuric","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology Institute for Oncology and Radiology of Serbia (IORS)  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Stojanovic\u2010Rundic","sequence":"additional","affiliation":[{"name":"Clinic for Radiation Oncology Institute for Oncology and Radiology of Serbia (IORS)  Belgrade Serbia"},{"name":"Faculty of Medicine University of Belgrade  Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radmila","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology Institute for Oncology and Radiology of Serbia (IORS)  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Castellvi\u2010Bel","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Fundaci\u00f3 Cl\u00ednic per la Recerca Biom\u00e8dica\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Hospital Cl\u00ednic University of Barcelona  Spain"},{"name":"Gastroenterology August Pi i Sunyer Biomedical Research Institute (IDIBAPS), CIBEREHD, Hospital Cl\u00ednic Barcelona  Spain"},{"name":"Faculty of Medicine and Health Sciences University of Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2076-5521","authenticated-orcid":false,"given":"Remond J.A.","family":"Fijneman","sequence":"additional","affiliation":[{"name":"Department of Pathology The Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Vlahou","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biomedical Research Foundation Academy of Athens (BRFAA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Zoidakis","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biomedical Research Foundation Academy of Athens (BRFAA)  Athens Greece"},{"name":"Department of Biology National and Kapodistrian University of Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7604-9295","authenticated-orcid":false,"given":"Milena","family":"Cavic","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology Institute for Oncology and Radiology of Serbia (IORS)  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray F","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092577","article-title":"Are colon and Rectal cancer two different tumor entities? 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