{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:54:07Z","timestamp":1791370447372,"version":"4.3.1"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009845","name":"Ovarian Cancer Research Foundation","doi-asserted-by":"publisher","award":["2018001167"],"award-info":[{"award-number":["2018001167"]}],"id":[{"id":"10.13039\/100009845","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>\n                    Ovarian cancer is the most lethal gynecological malignancy, due to late\u2010stage diagnosis, tumor heterogeneity, and lack of biomarkers for early detection. Extracellular vesicles (EVs) in plasma and ascites offer a minimally invasive source of tumor\u2010derived information, yet their lipid composition and relationship to tumor heterogeneity remain poorly defined. We performed lipidomic profiling of EVs from plasma and ascites of high\u2010grade serous ovarian cancer patients and from ovarian cancer and control cell lines to identify signatures of tumor progression and microenvironmental interactions. A lipid panel enriched in ovarian cancer EVs was evaluated in EVs and plasma across two independent cohorts (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009146). Combined with CA125, this panel improved detection, particularly against benign adnexal masses, achieving an AUROC of 0.99 in the verification cohort in both formats. Ovarian cancer EVs preferentially accumulated triglycerides, including ether\u2010linked species, whereas parental cells were enriched in phospholipids and ceramides. EV lipid signatures reflected tumor\u2010associated metabolic reprogramming and captured tumor heterogeneity across cell models. These findings show that EV lipidomics from accessible biofluids offers a non\u2010invasive window into ovarian cancer metabolism and candidate biomarkers for patient stratification and monitoring.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70327","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:27:48Z","timestamp":1791368868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer"],"prefix":"10.1002","author":[{"given":"Shikha","family":"Rani","sequence":"first","affiliation":[{"name":"Translational Extracellular Vesicles in Obstetrics and Gynae\u2010Oncology Group, Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, Royal Brisbane and Women's Hospital The University of Queensland  Herston Australia"},{"name":"UQ Centre for Extracellular Vesicle Nanomedicine, Faculty of Health, Medicine and Behavioural Sciences The University of Queensland  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Guanzon","sequence":"additional","affiliation":[{"name":"Translational Extracellular Vesicles in Obstetrics and Gynae\u2010Oncology Group, Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, Royal Brisbane and Women's Hospital The University of Queensland  Herston Australia"},{"name":"UQ Centre for Extracellular Vesicle Nanomedicine, Faculty of Health, Medicine and Behavioural Sciences The University of Queensland  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lai","sequence":"additional","affiliation":[{"name":"Translational Extracellular Vesicles in Obstetrics and Gynae\u2010Oncology Group, Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, Royal Brisbane and Women's Hospital The University of Queensland  Herston Australia"},{"name":"UQ Centre for Extracellular Vesicle Nanomedicine, Faculty of Health, Medicine and Behavioural Sciences The University of Queensland  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherin","family":"Scholz\u2010Romero","sequence":"additional","affiliation":[{"name":"Translational Extracellular Vesicles in Obstetrics and Gynae\u2010Oncology Group, Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, Royal Brisbane and Women's Hospital The University of Queensland  Herston Australia"},{"name":"UQ Centre for Extracellular Vesicle Nanomedicine, Faculty of Health, Medicine and Behavioural Sciences The University of Queensland  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Reed","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Facility, Frazer Institute University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edita","family":"Ritmejeryte","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Facility, Frazer Institute University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Lourie","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland, Translational Research Institute  Woolloongabba Australia"},{"name":"Mater Health Services  South Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naven","family":"Chetty","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland, Translational Research Institute  Woolloongabba Australia"},{"name":"Mater Health Services  South Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaltin","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland, Translational Research Institute  Woolloongabba Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4474-0046","authenticated-orcid":false,"given":"Carlos","family":"Salomon","sequence":"additional","affiliation":[{"name":"Translational Extracellular Vesicles in Obstetrics and Gynae\u2010Oncology Group, Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, Royal Brisbane and Women's Hospital The University of Queensland  Herston Australia"},{"name":"UQ Centre for Extracellular Vesicle Nanomedicine, Faculty of Health, Medicine and Behavioural Sciences The University of Queensland  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ygyno.2014.02.038","article-title":"\u201cPlatinum resistant\u201d ovarian cancer: what is it, who to treat and how to measure benefit?","volume":"133","author":"Davis A","year":"2014","journal-title":"Gynecol Oncol"},{"issue":"7579","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"S217","DOI":"10.1038\/527S217a","article-title":"Ovarian cancer: beyond resistance","volume":"527","author":"Holmes D","year":"2015","journal-title":"Nature"},{"issue":"3","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel E","year":"2010","journal-title":"Am J 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