{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:08:32Z","timestamp":1788786512301,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>\n                    Head and neck squamous cell carcinomas (HNSCCs) are characterized by recurrent genetic alterations, including the inactivation of the tumor suppressor\n                    <jats:italic>TP53<\/jats:italic>\n                    gene and dysregulation of the\n                    <jats:italic>TP63<\/jats:italic>\n                    gene. The\n                    <jats:italic>TP63<\/jats:italic>\n                    gene encodes multiple isoforms, among which the N\u2010terminal truncated isoform \u0394Np63 is fundamental for the integrity of stratified epithelial tissues. We previously demonstrated that \u0394Np63 represses the expression of the lncRNA NEAT1. Here, we investigated the functional crosstalk between p53 and \u0394Np63 in modulating NEAT1 expression following genotoxic stress. We found that upon genotoxic insults, p53 activation and the concomitant downregulation of \u0394Np63 promote NEAT1 transcription. In p53\u2010proficient HNSCC cells, NEAT1 targeting leads to increased DNA damage, highlighting its potential role in maintaining genomic stability and facilitating efficient DNA repair. Importantly, we showed that histone deacetylase inhibitors (HDACis) upregulate NEAT1 expression independently of p53, and NEAT1 silencing enhances HDACis\u2010induced DNA damage. Overall, our findings establish NEAT1 as an early regulator of the DNA damage response in HNSCCs and suggest that combining NEAT1 targeting with HDAC inhibition may potentiate therapeutic efficacy, particularly in\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutant HNSCCs.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70331","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:17:56Z","timestamp":1788783476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of the\n                    <scp>lncRNA NEAT1<\/scp>\n                    by p53\u2010\n                    <scp>\u0394Np63<\/scp>\n                    crosstalk modulates the\n                    <scp>DNA<\/scp>\n                    damage response and therapeutic efficacy in\n                    <scp>HNSCC<\/scp>"],"prefix":"10.1002","author":[{"given":"Sara","family":"De Domenico","sequence":"first","affiliation":[{"name":"Institute of Translational Pharmacology (IFT), CNR  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"La Banca","sequence":"additional","affiliation":[{"name":"Institute of Translational Pharmacology (IFT), CNR  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"D'Amico","sequence":"additional","affiliation":[{"name":"Institute of Translational Pharmacology (IFT), CNR  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Scalera","sequence":"additional","affiliation":[{"name":"Clinical Trial Center, Biostatistics and Bioinformatics Unit, Department of Research, Diagnosis and Innovative Technologies IRCCS Regina Elena National Cancer Institute  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8776-1440","authenticated-orcid":false,"given":"Sara","family":"Nicolai","sequence":"additional","affiliation":[{"name":"Institute of Translational Pharmacology (IFT), CNR  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6311-2382","authenticated-orcid":false,"given":"Angelo","family":"Peschiaroli","sequence":"additional","affiliation":[{"name":"Institute of Translational Pharmacology (IFT), CNR  Rome 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